| Increases in heart rate and systolic blood pressure in anesthetized dogs affected with X-linked muscular dystrophy after cisatracurium administration: a retrospective study. | |
| | |
MedLine Citation:
|
PMID: 21477148 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Most patients affected with Duchenne muscular dystrophy (DMD) present with arrhythmias and cardiomyopathies. Drugs which potentially may induce tachycardia or hypertension could precipitate acute cardiac failure in these patients and should be avoided. Methods: Thirty anesthesia records of five experimental male golden retriever cross-bred dogs affected with X-linked muscular dystrophy (GRDM), a model of DMD, were retrospectively reviewed (DMD group). Anesthesia records were compared with those of 10 golden retriever dogs not affected with muscular dystrophy (control group). Records were excluded if dogs received anticholinergics or vasoactive amines. Anesthesia was induced with fentanyl followed by propofol, both intravenously. After orotracheal intubation, all dogs' lungs were mechanically ventilated. Anesthesia was maintained with infusion of fentanyl and propofol (DMD group) or isoflurane in oxygen (control group). Pure O(2) was provided to the DMD group. Cisatracurium (0.1 mg·kg(-1) ) was administered intravenously to all dogs. Five-min interval recordings of HR and systolic blood pressures (SAP) were obtained. Results: Immediately after the administration of cisatracurium, absolute values for HR and SAP significantly increased by 78.3 ± 37.0 b·min(-1) (115.4 ± 64.9%) and 33.0 ± 28.3 mmHg (33.5 ± 31.2%), respectively, in all DMD dogs and remained significantly increased for 10 and 30 min, respectively. Dogs in the control group did not show significant increases in HR or SAP after cisatracurium administration. All dogs recovered from anesthesia without complications. Conclusion: In this report, increases in HR and SAP could be associated with the administration of cisatracurium in individuals affected with X-linked muscular dystrophy. These cardiovascular changes deserve further investigation. |
| | |
Authors:
|
Francesco Staffieri; Margaret Sleeper; Maria Paula Larenza |
Related Documents
:
|
21485668 - Bedside percutaneous tracheostomy: a prospective randomised comparison of percutwist ve... 3024888 - Baroreflex sensitivity alteration following transient hemispheric ischaemia in rats: pr... 3931088 - Prostaglandin modulation of the vascular effects of vasopressin in the conscious rat. 2962018 - Effect of intraventricular administration of calcium and calmodulin antagonist on the b... 18218918 - Effect of airways constriction on exhaled nitric oxide. 21485668 - Bedside percutaneous tracheostomy: a prospective randomised comparison of percutwist ve... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-8 |
Journal Detail:
|
Title: Paediatric anaesthesia Volume: - ISSN: 1460-9592 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Matthew J. Ryan Veterinary Hospital, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA Dipartimento dell'Emergenza e dei Trapianti d'Organo, Sezione di Chirurgia Veterinaria, Università degli Studi di Bari, Bari, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nasal foreign bodies in children: considerations for the anesthesiologist.
Next Document: Medication administration hassles for Mexican American family caregivers of older adults.