| Increases in glomerular eicosanoid production in rats with bilateral ureteral obstruction are mediated by enhanced enzyme activities of both the cyclooxygenase and 5-lipoxygenase pathways. | |
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MedLine Citation:
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PMID: 8390688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glomeruli isolated from rats with bilateral ureteral obstruction (BUO) of 24 hr duration produced significantly greater amounts of prostaglandin (PG) E2, 6-keto-PGF1 alpha, thromboxane B2, and leukotriene B4 than glomeruli isolated from sham-operated control (SOC) rats. To examine the mechanisms underlying the greater production of eicosanoids by glomeruli isolated from rats with BUO, we measured the activities of enzymes related to eicosanoid formation such as cyclooxygenase, 5-lipoxygenase, PGE2 isomerase, and PGI2 and thromboxane synthase in glomeruli isolated from SOC rats and rats with BUO. Glomeruli isolated from rats with BUO had a significantly increased activity of cyclooxygenase with de novo synthesis of this enzyme and a markedly augmented activities of PGE2 isomerase and both PGI2 and thromboxane synthases relative to glomeruli isolated from SOC rats. Similarly, the activity of membrane-bound 5-lipoxygenase, the active location of this enzyme, was significantly greater in glomeruli isolated from rats with BUO than in glomeruli isolated from SOC rats. Thus, BUO of 24 hr duration enhances the glomerular production of eicosanoids via the activation of enzymes in both the cyclooxygenase and 5-lipoxygenase pathways. |
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Authors:
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H Yanagisawa; Z Jin; N Kurihara; S Klahr; J Morrissey; O Wada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) Volume: 203 ISSN: 0037-9727 ISO Abbreviation: Proc. Soc. Exp. Biol. Med. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-07-16 Completed Date: 1993-07-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7505892 Medline TA: Proc Soc Exp Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 291-6 Citation Subset: IM |
Affiliation:
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Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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biosynthesis Animals Arachidonate 5-Lipoxygenase / metabolism* Cytochrome P-450 Enzyme System / metabolism Dinoprostone / biosynthesis Eicosanoids / biosynthesis* Female Intramolecular Oxidoreductases* Isomerases / metabolism Kidney Glomerulus / enzymology* Leukotriene B4 / biosynthesis Prostaglandin-Endoperoxide Synthases / metabolism* Rats Rats, Sprague-Dawley Thromboxane B2 / biosynthesis Thromboxane-A Synthase / metabolism Ureteral Obstruction / enzymology* |
| Grant Support | |
ID/Acronym/Agency:
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DK 07126/DK/NIDDK NIH HHS; DK 09976/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoids; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 71160-24-2/Leukotriene B4; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.13.11.34/Arachidonate 5-Lipoxygenase; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 5.-/Isomerases; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.99.3/prostaglandin-E synthase; EC 5.3.99.4/prostacyclin synthetase; EC 5.3.99.5/Thromboxane-A Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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