Document Detail

Increases in coronary vein CO2 during cardiac resuscitation.
MedLine Citation:
PMID:  2112125     Owner:  NLM     Status:  MEDLINE    
We investigated the aortic, mixed venous, and great cardiac vein acid-base changes in eight domestic pigs during cardiac arrest produced by ventricular fibrillation and during cardiopulmonary resuscitation (CPR). The great cardiac vein PCO2 increased from a control value of 52 +/- 2 to 132 +/- 28 (SD) Torr during CPR, whereas the arterial PCO2 was unchanged (39 +/- 4 vs. 38 +/- 4). The coronary venoarterial PCO2 gradient, therefore, increased remarkably from 13 +/- 2 to 94 +/- 29 Torr. The simultaneously measured great cardiac vein lactate concentrations increased from 0.24 +/- 0.06 to 7.3 +/- 2.34 mmol/l. Much more moderate increases in the lactate content of aortic blood from 0.64 +/- 0.25 to 2.56 +/- 0.27 mmol/l were observed. Increases in great cardiac vein PCO2 and lactate were highly correlated during CPR (r = 0.91). After successful CPR, the coronary venoarterial PCO2 gradient returned to normal levels within 2 min after restoration of spontaneous circulation. Lactate content was rapidly reduced and lactate extraction was reestablished within 30 min after CPR. These studies demonstrate marked but reversible acidosis predominantly as the result of myocardial CO2 production during CPR.
C V Gudipati; M H Weil; R J Gazmuri; H G Deshmukh; J Bisera; E C Rackow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  68     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1405-8     Citation Subset:  IM    
Department of Medicine, University of Health Sciences, Chicago Medical School Illinois 60064.
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MeSH Terms
Carbon Dioxide / blood*
Coronary Vessels*
Heart Arrest / blood*,  therapy
Hydrogen-Ion Concentration
Lactates / blood
Lactic Acid
Grant Support
1-RO1-HL-39148-01/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Lactates; 124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid

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