| Increases in body mass of rats during spaceflight: models and measurements. | |
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MedLine Citation:
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PMID: 11086667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that the body mass of rats is increased during spaceflight, we developed two models from the literature and obtained mass measurements during spaceflight. From studies of centrifugation (hypergravity), there is a reduction in body mass of rats dependent on the exposure gravity level. From data in 18 publications on rats subjected to hypergravity by centrifugation, we developed a model that predicted a 27% increase in body mass during the microgravity of spaceflight. Following spaceflight, with an increase in gravity on return to Earth, there is a reduction in body mass of rats for over 3 d. We related the reduction in body mass after spaceflight to the time after landing that mass measurements were made. From data in 23 publications on rats returning from spaceflight, we developed a model that predicted a 19% increase in body mass during spaceflight. Measurement of body mass of rats on days 6 and 10 of spaceflight found a 7 and 9% increase compared with ground control animals. The increase in body mass during spaceflight suggests that the rat may provide a viable model for metabolic studies in which changes during spaceflight may be predicted in part by ground-based hypergravity studies. |
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Authors:
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C E Wade; R M Ortiz; L A Baer |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Validation Studies |
Journal Detail:
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Title: Aviation, space, and environmental medicine Volume: 71 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-02-14 Completed Date: 2001-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1126-30 Citation Subset: IM; S |
Affiliation:
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Life Sciences Division, NASA Ames Research Center, Moffett Field, CA 94035-1000, USA. cwade@mail.arc.nasa.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Body Mass Index* Centrifugation / adverse effects Hypergravity / adverse effects Hypogravity / adverse effects* Male Models, Animal* Predictive Value of Tests Rats Rats, Sprague-Dawley Regression Analysis Space Flight* Time Factors Weightlessness Simulation / adverse effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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