Document Detail


Increases in SLT2 expression and chitin content are associated with incomplete killing of Candida glabrata by caspofungin.
MedLine Citation:
PMID:  18086838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Delta slt2 strain, suggesting a role for SLT2 and chitin production in the response of C. glabrata to caspofungin.
Authors:
Jason M Cota; Jodi L Grabinski; Robert L Talbert; David S Burgess; P David Rogers; Thomas D Edlind; Nathan P Wiederhold
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-17
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  52     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-26     Completed Date:  2008-09-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1144-6     Citation Subset:  IM    
Affiliation:
University of Texas at Austin College of Pharmacy, UTHSCSA, PERC MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / pharmacology*
Candida glabrata / drug effects*,  enzymology,  metabolism
Chitin / metabolism*
Drug Resistance, Fungal*
Echinocandins / pharmacology*
Fungal Proteins / genetics,  metabolism
Microbial Sensitivity Tests
Mitogen-Activated Protein Kinases / genetics,  metabolism*
Up-Regulation
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Echinocandins; 0/Fungal Proteins; 0/caspofungin; 1398-61-4/Chitin; EC 2.7.11.24/Mitogen-Activated Protein Kinases
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