Document Detail

Increases in B-type natriuretic peptide after acute mental stress in heart failure patients are associated with alcohol consumption.
MedLine Citation:
PMID:  20731986     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to investigate in heart failure (HF) patients whether acute mental stress induces increases in the HF-severity biomarker B-type natriuretic peptide (BNP) and if alcohol consumption is associated with such stress-induced increases.
METHOD: Twenty-one male HF patients and 19 male non-HF controls (M = 56 years, SEM = 2) underwent a 15-minute acute mental stress test combining public speaking and mental arithmetic. Plasma levels of BNP were determined immediately before as well as 2 hours after the stress test. Alcohol consumption was assessed by self-reported number of drinks per month and history of use.
RESULTS: HF patients had higher BNP levels before and after stress, F(1, 38) = 23.42, p < .001, and showed greater stress-induced increases in BNP levels, F(1, 38) = 4.52, p = .04, compared with controls. HF status (beta = .32, p = .015, deltaR(2) = .10) and higher alcohol consumption ((beta = .61, p< .001, deltaR(2) = .37) were independently associated with higher BNP stress increases. Moreover, higher alcohol consumption moderated the greater BNP stress increases in HF patients but not in controls (p = .49, p < .001, delta(2) = .20), although alcohol consumption did not differ between groups.
CONCLUSIONS: For individuals with HF, particularly those who drink moderate to more substantial amounts of alcohol, exposure to acute psychological stress leads to increases in circulating levels of BNP, a biomarker which is associated with increased morbidity and mortality in HF.
Petra H Wirtz; Laura S Redwine; Suzi Hong; Thomas Rutledge; Joel E Dimsdale; Barry H Greenberg; Paul J Mills
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of studies on alcohol and drugs     Volume:  71     ISSN:  1938-4114     ISO Abbreviation:  J Stud Alcohol Drugs     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2011-05-31     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101295847     Medline TA:  J Stud Alcohol Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  786-94     Citation Subset:  IM    
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
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MeSH Terms
Acute Disease
Aged, 80 and over
Alcohol Drinking / blood*,  psychology
Biological Markers / blood
Heart Failure / blood*,  complications,  psychology
Middle Aged
Natriuretic Peptide, Brain / biosynthesis*,  blood
Neuropsychological Tests
Stress, Psychological / blood*,  complications,  psychology
Up-Regulation / physiology*
Grant Support
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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