| Increases in B-type natriuretic peptide after acute mental stress in heart failure patients are associated with alcohol consumption. | |
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MedLine Citation:
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PMID: 20731986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to investigate in heart failure (HF) patients whether acute mental stress induces increases in the HF-severity biomarker B-type natriuretic peptide (BNP) and if alcohol consumption is associated with such stress-induced increases. METHOD: Twenty-one male HF patients and 19 male non-HF controls (M = 56 years, SEM = 2) underwent a 15-minute acute mental stress test combining public speaking and mental arithmetic. Plasma levels of BNP were determined immediately before as well as 2 hours after the stress test. Alcohol consumption was assessed by self-reported number of drinks per month and history of use. RESULTS: HF patients had higher BNP levels before and after stress, F(1, 38) = 23.42, p < .001, and showed greater stress-induced increases in BNP levels, F(1, 38) = 4.52, p = .04, compared with controls. HF status (beta = .32, p = .015, deltaR(2) = .10) and higher alcohol consumption ((beta = .61, p< .001, deltaR(2) = .37) were independently associated with higher BNP stress increases. Moreover, higher alcohol consumption moderated the greater BNP stress increases in HF patients but not in controls (p = .49, p < .001, delta(2) = .20), although alcohol consumption did not differ between groups. CONCLUSIONS: For individuals with HF, particularly those who drink moderate to more substantial amounts of alcohol, exposure to acute psychological stress leads to increases in circulating levels of BNP, a biomarker which is associated with increased morbidity and mortality in HF. |
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Authors:
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Petra H Wirtz; Laura S Redwine; Suzi Hong; Thomas Rutledge; Joel E Dimsdale; Barry H Greenberg; Paul J Mills |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of studies on alcohol and drugs Volume: 71 ISSN: 1938-4114 ISO Abbreviation: J Stud Alcohol Drugs Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2011-05-31 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 101295847 Medline TA: J Stud Alcohol Drugs Country: United States |
Other Details:
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Languages: eng Pagination: 786-94 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of California, San Diego, La Jolla, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Aged, 80 and over Alcohol Drinking / blood*, psychology Biological Markers / blood Heart Failure / blood*, complications, psychology Humans Male Middle Aged Natriuretic Peptide, Brain / biosynthesis*, blood Neuropsychological Tests Stress, Psychological / blood*, complications, psychology Up-Regulation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HL-073355/HL/NHLBI NIH HHS; HL-7265/HL/NHLBI NIH HHS; RR-00827/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
| Comments/Corrections | |
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