Document Detail


Increases and decreases of whole-arm heterochromatin in specific chromosomes: an extraordinary situation in hybrids of the Mus terricolor complex.
MedLine Citation:
PMID:  12438806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The three chromosomal species of Mus terricolor display fixed variations in the short-arm heterochromatin of autosomes 1, 3, and 6. Some laboratory-generated hybrids among the chromosomal species show an unusual increase or decrease in the extent of whole-arm heterochromatin, instead of the expected heterozygosity for the heterochromatic short arms. The whole-arm increase/decrease tends to favor homozygosity for the presence or absence of the heterochromatic short arms. Interestingly, this increase/decrease conforms with the karyotypes of the parental chromosomal species. Although rapid karyotypic changes have been reported in other plant and animal hybrids, the situation observed in the M. terricolor hybrids is unique. The changes are stable and could be a product of the unusual chromosomal organization of recombinogenic telomeric sequences in this species complex. The altered karyological constitution is constant in both somatic and germ cells of each hybrid, suggesting that the changes occurred early in their development. The high frequency and nonrandom recurrence of similar changes in different hybrids seem to reflect a mechanism that might have been instrumental in the fixation of these chromosomal variations in a stable homozygous condition in natural populations.
Authors:
T Sharma; A Bardhan; M Bahadur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytogenetic and genome research     Volume:  96     ISSN:  1424-8581     ISO Abbreviation:  Cytogenet. Genome Res.     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-19     Completed Date:  2003-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101142708     Medline TA:  Cytogenet Genome Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  244-9     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Affiliation:
Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, India. tsharma@banaras.ernet.in
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Mapping*
Heterochromatin / genetics*
Karyotyping
Mice / genetics*
Models, Genetic
Nucleic Acid Hybridization
Chemical
Reg. No./Substance:
0/Heterochromatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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