Document Detail


Increased xanthine oxidase during labour--implications for oxidative stress.
MedLine Citation:
PMID:  9364609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Xanthine dehydrogenase/oxidase (XDH/XO) produces uric acid. When in the oxidase form, this production is coupled with the generation of free radicals. Hypoxia-reperfusion enhances conversion of XDH to XO. Since the placenta is exposed to short periods of hypoxia reperfusion during labour, 17 placentae of pregnancy terminated by elective caesarean section and five placentae of pregnancies terminated by caesarean section during labour were examined for XDH/XO activity. It was found that XO activity was higher in the placentae of labouring women (P = 0.003), which suggests that labour enhances conversion of XDH to XO, facilitating free radical production.
Authors:
A Many; J M Roberts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Placenta     Volume:  18     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-11     Completed Date:  1997-12-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  725-6     Citation Subset:  IM    
Affiliation:
Magee Womens Research Institute, University of Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cesarean Section
Female
Humans
Labor, Obstetric / physiology*
Oxidative Stress / physiology
Placenta / enzymology*
Pregnancy
Xanthine Dehydrogenase / metabolism
Xanthine Oxidase / metabolism*
Grant Support
ID/Acronym/Agency:
P01 HD30367/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
EC 1.17.1.4/Xanthine Dehydrogenase; EC 1.17.3.2/Xanthine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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