| Increased vulnerability to alcohol-related birth defects in the offspring of mothers over 30. | |
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MedLine Citation:
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PMID: 8730230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The risk of fetal alcohol syndrome (FAS) is known to increase with increased maternal age and parity. This study investigated the hypothesis that the deficits in growth and intellectual function seen in non-FAS infants exposed to alcohol at moderate-to-heavy levels are also found disproportionately in the offspring of older mothers. Mothers of 480 African-American, inner-city infants were interviewed at each prenatal clinic visit regarding their use of alcohol during pregnancy. Infants were assessed for physical growth and cognitive development repeatedly through age 13 months. In analyses run separately for the infants of younger and older mothers, alcohol-related deficits were seen most strongly in the offspring of women over 30 years of age. This pattern was not caused by lower levels of drinking by the younger mothers. Age-related increases in maternal body fat-to-water ratio and a faster rate of alcohol metabolism in chronic drinking women may account for the greater vulnerability of the offspring of the older mothers. These data suggest that physiological changes associated with aging and/or chronic drinking may play an important role in the alcohol-related birth defects seen in infants exposed at moderate-to-heavy levels. |
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Authors:
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J L Jacobson; S W Jacobson; R J Sokol |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Alcoholism, clinical and experimental research Volume: 20 ISSN: 0145-6008 ISO Abbreviation: Alcohol. Clin. Exp. Res. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-10-02 Completed Date: 1996-10-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7707242 Medline TA: Alcohol Clin Exp Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 359-63 Citation Subset: IM |
Affiliation:
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Psychology Department, Wayne State University, Detroit, MI 48202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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African Continental Ancestry Group* Alcohol Drinking / adverse effects Cross-Sectional Studies Dose-Response Relationship, Drug Female Fetal Alcohol Syndrome / diagnosis, epidemiology* Follow-Up Studies Humans Incidence Infant Infant, Newborn Intelligence Tests Male Maternal Age* Neuropsychological Tests Parity Pregnancy Urban Population / statistics & numerical data* |
| Grant Support | |
ID/Acronym/Agency:
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P50-AA0706/AA/NIAAA NIH HHS; R01 AA06966/AA/NIAAA NIH HHS; R01-AA09524/AA/NIAAA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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