Document Detail


Increased vulnerability to alcohol-related birth defects in the offspring of mothers over 30.
MedLine Citation:
PMID:  8730230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The risk of fetal alcohol syndrome (FAS) is known to increase with increased maternal age and parity. This study investigated the hypothesis that the deficits in growth and intellectual function seen in non-FAS infants exposed to alcohol at moderate-to-heavy levels are also found disproportionately in the offspring of older mothers. Mothers of 480 African-American, inner-city infants were interviewed at each prenatal clinic visit regarding their use of alcohol during pregnancy. Infants were assessed for physical growth and cognitive development repeatedly through age 13 months. In analyses run separately for the infants of younger and older mothers, alcohol-related deficits were seen most strongly in the offspring of women over 30 years of age. This pattern was not caused by lower levels of drinking by the younger mothers. Age-related increases in maternal body fat-to-water ratio and a faster rate of alcohol metabolism in chronic drinking women may account for the greater vulnerability of the offspring of the older mothers. These data suggest that physiological changes associated with aging and/or chronic drinking may play an important role in the alcohol-related birth defects seen in infants exposed at moderate-to-heavy levels.
Authors:
J L Jacobson; S W Jacobson; R J Sokol
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  20     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-10-02     Completed Date:  1996-10-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
Affiliation:
Psychology Department, Wayne State University, Detroit, MI 48202, USA.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group*
Alcohol Drinking / adverse effects
Cross-Sectional Studies
Dose-Response Relationship, Drug
Female
Fetal Alcohol Syndrome / diagnosis,  epidemiology*
Follow-Up Studies
Humans
Incidence
Infant
Infant, Newborn
Intelligence Tests
Male
Maternal Age*
Neuropsychological Tests
Parity
Pregnancy
Urban Population / statistics & numerical data*
Grant Support
ID/Acronym/Agency:
P50-AA0706/AA/NIAAA NIH HHS; R01 AA06966/AA/NIAAA NIH HHS; R01-AA09524/AA/NIAAA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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