Document Detail


Increased von Willebrand factor in acute stroke patients with atrial fibrillation.
MedLine Citation:
PMID:  17904039     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Plasma level of von Willebrand factor (vWF) is a useful marker not only for endothelial dysfunction, but also for left atrial thrombogenesis. We measured plasma levels of vWF antigen and other coagulation and fibrinolysis markers in 183 consecutive patients with acute ischemic stroke and compared these data between patients with and without atrial fibrillation (AF). vWF correlated with severity, outcome, and infarct size and were significantly higher in the AF group than in the non-AF group. The positive correlations of vWF with plasmin-alpha2 plasmin inhibitor complex and soluble fibrin monomer complex, and higher levels of vWF in patients with than without spontaneous echo contrast, indicate thrombogenesis in the left atrium. Plasma levels of vWF may reflect thrombogenesis in patients with AF.
Authors:
Mika Sato; Akifumi Suzuki; Ken Nagata; Shinichiro Uchiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  15     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  -    
Affiliation:
Department of Stroke Care Unit, Research Institute for Brain and Blood Vessels, Akita, Japan.
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