Document Detail

Increased volume of tracheal aspirate fluid predicts the development of bronchopulmonary dysplasia.
MedLine Citation:
PMID:  22980969     Owner:  NLM     Status:  Publisher    
BACKGROUND: Elevated cytokine concentrations were observed in tracheal aspirate fluid (TAF) of infants on mechanical ventilation who subsequently developed bronchopulmonary dysplasia (BPD). However, there are few reports that systematically evaluate the amount of TAF as an indicator of BPD development. AIM: To clarify whether TAF volume during the first week of life predicts BPD development in extremely low gestational age newborns (ELGANs). STUDY DESIGN: We analyzed 51 infants, born at gestational age of <28weeks and ventilated for more than 7days after birth, among whom, 26 were diagnosed with BPD based on the clinical definition of oxygen dependence at 36weeks postmenstrual age (BPD group) and 25 were included in the non-BPD group. Sum of TAF scores (STS) was calculated by semi-quantification of TAF volume at each suctioning and the suctioning frequency during the first week of life. RESULTS: STS was significantly higher in the BPD group than in the non-BPD group (median (interquartile range): 77 (29-126) vs. 28 (22-59), p<0.001). STS (cut-off, 60) with area under the curve in receiver operating analysis of 0.75 was significantly predictive of BPD development. Multivariate logistic regression analysis adjusted for perinatal characteristics showed that STS≥60 was a significant risk factor for BPD development (odds ratio, 7.50; confidence interval, 1.16-48.40, p=0.034). CONCLUSION: Increased TAF volume during the first week of life was an independent predictor for BPD development in ventilated ELGANs, indicating that increased pulmonary capillary permeability may influence the pathogenesis of BPD.
Sota Iwatani; Masami Mizobuchi; Satoshi Tanaka; Kei Inomata; Hitomi Sakai; Seiji Yoshimoto; Hideto Nakao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-12
Journal Detail:
Title:  Early human development     Volume:  -     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Department of Neonatology, Hyogo Prefectural Kobe Children's Hospital Perinatal Center, 1-1-1 Takakuradai, Suma-Ku, Kobe, Hyogo 654-0081, Japan. Electronic address:
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