Document Detail


Increased vitamin E intake is associated with higher alpha-tocopherol concentration in the maternal circulation but higher alpha-carboxyethyl hydroxychroman concentration in the fetal circulation.
MedLine Citation:
PMID:  21159788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The transfer of vitamin E across the placenta is limited, but no data exist on the concentrations of vitamin E metabolites carboxyethyl hydroxychromans (α- and γ-CEHCs) in the fetal circulation.
OBJECTIVE: We measured α- and γ-CEHC concentrations in maternal and umbilical cord blood pairs and examined their relations to circulating vitamin E (α- and γ-tocopherol) and maternal dietary vitamin E intake.
DESIGN: Healthy, pregnant women were enrolled from Oregon Health and Science University's obstetric clinic (<22 wk gestation), and at least one fasting blood sample and a previous day's 24-h diet recall were collected during their pregnancy (n = 19). Umbilical cord blood samples were obtained at the time of delivery and were analyzed for α- and γ-tocopherol, α- and γ-CEHC, and total lipid concentrations.
RESULTS: Mean (±SD) concentrations of umbilical cord blood α-CEHC (30.2 ± 28.9 nmol/L) and γ-CEHC (104.5 ± 61.3 nmol/L) were not significantly different from maternal concentrations (P = 0.07 and 0.08, respectively), but metabolite:tocopherol ratios were significantly higher in cord blood (P < 0.01 and 0.001, respectively). Maternal α-tocopherol:total lipids ratios were correlated with cord blood α-CEHCs (r = 0.67, P = 0.004), and higher vitamin E intakes were associated with higher cord blood α-CEHC concentrations (r = 0.75, P < 0.003).
CONCLUSION: Higher maternal intake of vitamin E during pregnancy may result in increased metabolite concentrations in the fetal circulation, suggesting increased maternal or fetal liver metabolism of vitamin E. This trial was registered at clinicaltrials.gov as NCT00632476.
Authors:
Svetlana Didenco; Melanie B Gillingham; Mitzi D Go; Scott W Leonard; Maret G Traber; Cindy T McEvoy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-15
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  93     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-21     Completed Date:  2011-02-25     Revised Date:  2013-08-08    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  368-73     Citation Subset:  AIM; IM    
Affiliation:
Graduate Programs in Human Nutrition, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00632476
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromans / blood*
Diet*
Diet Records
Female
Fetal Blood / chemistry*
Humans
Lipids / blood
Maternal-Fetal Exchange*
Pregnancy / blood*
Umbilical Cord
Vitamin E / administration & dosage*
Young Adult
alpha-Tocopherol / blood*
Grant Support
ID/Acronym/Agency:
HL080231/HL/NHLBI NIH HHS; R01 DK081761/DK/NIDDK NIH HHS; ULI RR024140/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Chromans; 0/Lipids; 0/carboxyethyl-hydroxychroman; 1406-18-4/Vitamin E; 59-02-9/alpha-Tocopherol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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