Document Detail


Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee.
MedLine Citation:
PMID:  18067512     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to characterize the extent and distribution of the large aggregating proteoglycan versican in patients with patellar tendinosis. We obtained tendon from tendinopathy patients undergoing debridement of the patellar tendon and from controls undergoing intramedullary tibial nailing. Versican content was investigated by Western blotting and immunohistochemistry. Microvessel thickness and density were determined using computer-assisted image analysis. Markers for smooth muscle actin, endothelial cells (CD31) and proliferating cells (Ki67) were examined immunohistochemically. Western blot analysis and immunohistochemical staining revealed elevated versican content in the proximal patellar tendon of tendinosis patients (P=0.042). Versican content was enriched in regions of fibrocartilage metaplasia and fibroblast proliferation, as well as in the perivascular matrix of proliferating microvessels and within the media and intima of arterioles. Microvessel density was higher in tendinosis tissue compared with control tissue. Versican deposition is a prominent feature of patellar tendinosis. Because this molecule is not only a component of normal fibrocartilagenous matrices but also implicated in a variety of soft tissue pathologies, future studies should further detail both pathological and adaptive roles of versican in tendons.
Authors:
A Scott; Ø Lian; C R Roberts; J L Cook; C J Handley; R Bahr; T Samiric; M Z Ilic; J Parkinson; D A Hart; V Duronio; K M Khan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-07
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  18     ISSN:  1600-0838     ISO Abbreviation:  Scand J Med Sci Sports     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-12-30     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  427-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Athletic Injuries / metabolism*,  pathology
Biopsy
Blotting, Western
Case-Control Studies
Extracellular Matrix / metabolism
Female
Humans
Immunohistochemistry
Knee Injuries / metabolism*,  pathology
Male
Patellar Ligament / metabolism*,  pathology
Tendinopathy / metabolism*,  pathology
Versicans / metabolism*
Grant Support
ID/Acronym/Agency:
78141-1//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
126968-45-4/Versicans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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