Document Detail

Increased venous-arterial carbon dioxide tension difference during severe sepsis in rats.
MedLine Citation:
PMID:  8124954     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that decreases in blood flow during septic shock lead to increases in the venous-arterial PCO2 difference in a rat model of sepsis. DESIGN: Prospective, randomized, controlled experimental study. SETTING: Research laboratory. SUBJECTS: Fifteen Sprague-Dawley rats. INTERVENTIONS: Severe sepsis was induced by cecal ligation and perforation. Ten animals were randomized to no treatment or fluid infusion to maintain the cardiac output at baseline values. An additional five rats served as sham-operated controls. MEASUREMENTS AND MAIN RESULTS: Hemodynamic measurements, arterial and central venous blood gases were obtained at baseline, and then at 3 hrs and 6 hrs after abdominal surgery. In the five septic rats that did not receive volume infusion, cardiac output decreased from 331 +/- 32 to 172 +/- 9 mL/min/kg (p < .001). This decrease in cardiac output was associated with an increase of 13 +/- 2 torr (1.7 +/- 0.2 kPa) in the venous-arterial PCO2 difference (p < .001). Furthermore, the venous-arterial PCO2 gradient correlated linearly with the cardiac output in the same animals (r2 = .52, p < .001). In the septic animals that received volume infusion and in sham animals, cardiac output and the venous-arterial PCO2 remained unchanged from baseline at 6 hrs. CONCLUSION: We conclude that the increase in the venous-arterial PCO2 gradient in severe sepsis appears to be related to reductions in cardiac output.
E C Rackow; M E Astiz; C E Mecher; M H Weil
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  22     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-14     Completed Date:  1994-04-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-5     Citation Subset:  AIM; IM; S    
Department of Medicine, St. Vincent's Hospital, New York, NY 10011.
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MeSH Terms
Acidosis / metabolism
Carbon Dioxide / blood*
Cardiac Output
Hydrogen-Ion Concentration
Hypercapnia / metabolism*
Rats, Sprague-Dawley
Shock, Septic / metabolism*
Reg. No./Substance:
124-38-9/Carbon Dioxide
Comment In:
Crit Care Med. 1994 Jan;22(1):9-10   [PMID:  8124982 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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