Document Detail

Increased urotensin II plasma levels in patients with cirrhosis and portal hypertension.
MedLine Citation:
PMID:  12445417     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Vasodilatation--despite activation of endogenous vasoconstrictors--is pronounced in portal hypertension. We therefore investigated the role of Urotensin II (U II), a newly described peptide reported to be a vasoconstrictor in the central arterial compartment and a vasodilator in the splanchnic vasculature. METHODS: U II immunoreactivity was measured in 50 patients with cirrhosis and in 15 healthy controls. U II levels were compared in portal venous and central venous blood of 30 patients immediately before transjugular intrahepatic porto-systemic stent shunt implantation. RESULTS: U II levels (median, range, ng/ml) were significantly increased in cirrhotics (12.3, 1.6-41.4) compared to controls (3.6, 0.1-12.0; P<0.001). In patients with cirrhosis, U II levels were significantly higher in central venous (12.9, 2.5-41.4) than in portal venous blood (11.0, 0.6-31.9; P<0.005). U II levels were higher in ascitic than in non-ascitic patients (P<0.02). They correlated positively with the wedged hepatic venous pressure gradient (rho=0.34, P<0.005) and negatively with the mean arterial pressure (rho=-0.41; P<0.001). CONCLUSIONS: Urotensin II formation is upregulated in patients with cirrhosis and portal hypertension. The transhepatic gradient suggests a hepatic production of this peptide.
Jörg Heller; Michael Schepke; Markus Neef; Rainer Woitas; Christian Rabe; Tilman Sauerbruch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hepatology     Volume:  37     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  767-72     Citation Subset:  IM    
Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany.
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MeSH Terms
Ascites / etiology
Case-Control Studies
Central Venous Pressure
Hypertension, Portal / blood*,  etiology*,  physiopathology,  surgery
Liver Cirrhosis / blood*,  complications*,  physiopathology
Middle Aged
Portasystemic Shunt, Transjugular Intrahepatic
Severity of Illness Index
Urotensins / blood*
Venous Pressure
Reg. No./Substance:
0/Urotensins; 9047-55-6/urotensin II

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