| Increased urotensin II plasma levels in patients with cirrhosis and portal hypertension. | |
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MedLine Citation:
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PMID: 12445417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Vasodilatation--despite activation of endogenous vasoconstrictors--is pronounced in portal hypertension. We therefore investigated the role of Urotensin II (U II), a newly described peptide reported to be a vasoconstrictor in the central arterial compartment and a vasodilator in the splanchnic vasculature. METHODS: U II immunoreactivity was measured in 50 patients with cirrhosis and in 15 healthy controls. U II levels were compared in portal venous and central venous blood of 30 patients immediately before transjugular intrahepatic porto-systemic stent shunt implantation. RESULTS: U II levels (median, range, ng/ml) were significantly increased in cirrhotics (12.3, 1.6-41.4) compared to controls (3.6, 0.1-12.0; P<0.001). In patients with cirrhosis, U II levels were significantly higher in central venous (12.9, 2.5-41.4) than in portal venous blood (11.0, 0.6-31.9; P<0.005). U II levels were higher in ascitic than in non-ascitic patients (P<0.02). They correlated positively with the wedged hepatic venous pressure gradient (rho=0.34, P<0.005) and negatively with the mean arterial pressure (rho=-0.41; P<0.001). CONCLUSIONS: Urotensin II formation is upregulated in patients with cirrhosis and portal hypertension. The transhepatic gradient suggests a hepatic production of this peptide. |
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Authors:
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Jörg Heller; Michael Schepke; Markus Neef; Rainer Woitas; Christian Rabe; Tilman Sauerbruch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hepatology Volume: 37 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2003-06-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 767-72 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany. jheller@uni-bonn.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Ascites / etiology Case-Control Studies Central Venous Pressure Female Humans Hypertension, Portal / blood*, etiology*, physiopathology, surgery Liver Cirrhosis / blood*, complications*, physiopathology Male Middle Aged Portasystemic Shunt, Transjugular Intrahepatic Severity of Illness Index Up-Regulation Urotensins / blood* Venous Pressure |
| Chemical | |
Reg. No./Substance:
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0/Urotensins; 9047-55-6/urotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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