Document Detail

Increased urinary transferrin excretion in exercising normoalbuminuric insulin-dependent diabetic patients.
MedLine Citation:
PMID:  1720297     Owner:  NLM     Status:  MEDLINE    
The median rate of urinary transferrin excretion is greatly increased by exercise in subjects with uncomplicated type 1 (insulin-dependent) diabetes. This increase is proportionally far greater than that seen in urinary albumin excretion rate after the same exercise. Non-diabetic control subjects showed no rise in urinary transferrin excretion rate following exercise. N-acetyl-beta-D-glucosaminidase excretion rate was higher in diabetic than control groups but did not rise with exercise. Our results suggest that patients with apparently uncomplicated diabetes have abnormal renal function. In this group an elevated urinary transferrin excretion rate appears to be a more sensitive indicator of altered renal function than is elevated albumin excretion rate. The mechanism underlying exercise-induced urinary loss of transferrin remains to be elucidated.
M J O'Donnell; P Martin; D Cavan; A Parkes; J Chapman; C Chapman; A H Barnett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  28 ( Pt 5)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-30     Completed Date:  1991-12-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  456-60     Citation Subset:  IM    
Department of Medicine, University of Birmingham, UK.
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MeSH Terms
Acetylglucosaminidase / urine
Albuminuria / urine
Alpha-Globulins / urine
Diabetes Mellitus, Type 1 / urine*
Diabetic Nephropathies / urine
Protease Inhibitors / urine
Transferrin / urine*
Reg. No./Substance:
0/Alpha-Globulins; 0/Protease Inhibitors; 0/alpha-1-microglobulin; 11096-37-0/Transferrin; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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