Document Detail


Increased urinary transferrin excretion in exercising normoalbuminuric insulin-dependent diabetic patients.
MedLine Citation:
PMID:  1720297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The median rate of urinary transferrin excretion is greatly increased by exercise in subjects with uncomplicated type 1 (insulin-dependent) diabetes. This increase is proportionally far greater than that seen in urinary albumin excretion rate after the same exercise. Non-diabetic control subjects showed no rise in urinary transferrin excretion rate following exercise. N-acetyl-beta-D-glucosaminidase excretion rate was higher in diabetic than control groups but did not rise with exercise. Our results suggest that patients with apparently uncomplicated diabetes have abnormal renal function. In this group an elevated urinary transferrin excretion rate appears to be a more sensitive indicator of altered renal function than is elevated albumin excretion rate. The mechanism underlying exercise-induced urinary loss of transferrin remains to be elucidated.
Authors:
M J O'Donnell; P Martin; D Cavan; A Parkes; J Chapman; C Chapman; A H Barnett
Related Documents :
899037 - Cardenolide analogues. vi. the metabolism of the prodrug diacetylcymarol in the rat.
22688987 - Proteomic investigation of changes in rat skeletal muscle after exercise-induced fatigue.
24377907 - Endurance exercise training improves heart rate recovery in patients with copd.
3190987 - Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in ma...
8629777 - Reassessing the need for ventilation during cpr.
10518297 - Effects of practice on the ability to perform lumbar stabilization exercises.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  28 ( Pt 5)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-30     Completed Date:  1991-12-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  456-60     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Birmingham, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylglucosaminidase / urine
Adult
Albuminuria / urine
Alpha-Globulins / urine
Diabetes Mellitus, Type 1 / urine*
Diabetic Nephropathies / urine
Exercise*
Humans
Male
Protease Inhibitors / urine
Transferrin / urine*
Chemical
Reg. No./Substance:
0/Alpha-Globulins; 0/Protease Inhibitors; 0/alpha-1-microglobulin; 11096-37-0/Transferrin; EC 3.2.1.52/Acetylglucosaminidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reversibility of age associated NK defect by endocrinological and/or nutritional intervention.
Next Document:  T cell receptor expression in Sjögren's syndrome.