| INCREASED URINARY PROTEIN EXCRETION IN THE 'NORMAL' RANGE IS ASSOCIATED WITH INCREASED RENIN ANGIOTENSIN SYSTEM ACTIVITY. | |
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MedLine Citation:
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PMID: 22088437 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Increased levels of albuminuria and proteinuria, both linked to augmented renin angiotensin system (RAS) activity, are associated with adverse cardiovascular and kidney events. However, the relationship between variations in urinary albumin excretion (UAE) and total protein excretion (UTPE) in the normal range and RAS activity is unclear. We examined the association between UAE and UTPE and hemodynamic response to angiotensin II (AngII) challenge, a well-accepted indirect measure of RAS activity, in healthy individuals with normal UAE and UTPE. Forty subjects (15 men, 25 women; age, 38±2yrs; UAE, 3.32±0.55mg/day; UTPE, 56.8±3.6mg/day), were studied in high salt balance. Blood pressure (BP), arterial stiffness determined by applanation tonometry, and circulating RAS components were measured at baseline and in response to graded AngII infusion. The primary outcome was the BP response to AngII challenge at 30 and 60 minutes. UAE was associated with a blunted diastolic BP response to AngII infusion (30min, p=0.005; 60min, p=0.17), a relationship which remained even after adjustment (30min, p<0.001; 60min, p=0.035). Similar results were observed with UTPE (30min, p=0.031; 60min, p=0.001), even after multivariate analysis (30min, p=0.008; 60min, p=0.001). Neither UAE nor UTPE were associated with the systolic BP, circulating RAS component, or arterial stiffness responses to AngII challenge. Among healthy individuals with UAE and UTPE in the normal range, increased levels of these measures were independently associated with a blunted diastolic BP response to AngII indicating increased vascular RAS activity, which is known to be deleterious to both cardiac and renal function. |
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Authors:
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David Donald McTavish Nicholl; Brenda R Hemmelgarn; Tanvir C Turin; Jennifer M Macrae; Daniel A Muruve; Darlene Y Sola; Sofia B Ahmed |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: - ISSN: 1522-1466 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Calgary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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