| Increased urinary nitrite excretion in children with minimal change nephrotic syndrome. | |
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MedLine Citation:
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PMID: 8636807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We tested the hypothesis that nitric oxide synthesis by the kidney is increased in children with primary nephrotic syndrome. METHODS: We examined the urinary excretion of nitrite, a stable metabolite of nitric oxide, using the Griess reaction, in children with nephrotic syndrome. RESULTS: In comparison with healthy children, patients with minimal change nephrotic syndrome had increased urinary nitrite excretion regardless of whether the disease was in relapse or remission (p < 0.025). In contrast, urinary nitrite excretion was similar in control subjects and patients with focal segmental glomerulosclerosis or IgA nephropathy. CONCLUSION: These findings indicate that measurement of urinary nitrite excretion may be a useful test to help discriminate between minimal change nephrotic syndrome and focal segmental glomerulosclerosis in children with idiopathic nephrotic syndrome. |
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Authors:
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H Trachtman; B Gauthier; R Frank; S Futterweit; A Goldstein; J Tomczak |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 128 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-07-05 Completed Date: 1996-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 173-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Schneider Children's Hospital, Long Island Jewish Medical Center, New Hyde Park, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenal Cortex Hormones / administration & dosage, therapeutic use Adult Child Child, Preschool Creatinine / blood Female Glomerulonephritis, IGA / urine Glomerulosclerosis, Focal Segmental / urine Humans Infant Male Nephrosis, Lipoid / drug therapy, urine* Nitric Oxide Synthase / metabolism Nitrites / urine* Recurrence Remission, Spontaneous |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Nitrites; 60-27-5/Creatinine; EC 1.14.13.39/Nitric Oxide Synthase |
| Comments/Corrections | |
Comment In:
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J Pediatr. 1997 Jan;130(1):161
[PMID:
9003868
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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