| Increased urinary excretion of nephrin, podocalyxin, and βig-h3 in women with preeclampsia. | |
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MedLine Citation:
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PMID: 22301621 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Emerging evidence has shown that podocyte injury and reduced specific podocyte protein expressions contribute to proteinuria in preeclampsia. We collected urine specimens from women with preeclampsia to study if podocyte specific protein shedding associates with renal barrier dysfunction. Urine specimens from women with normal pregnancies and from pregnant women complicated with chronic hypertension were used as comparison. We determined soluble podocyte slit protein nephrin levels in the urine specimens. Podocalyxin, βig-h3, and VEGF concentrations were also measured. We found that nephrin and podocalyxin were barely detectable in the urine specimens from normal pregnant women and from women complicated with chronic hypertension. In preeclampsia, urinary nephrin and podocalyxin concentrations were significantly increased and highly correlated to each other, r(2) = 0.595. Nephrin and podocalyxin with urine protein concentrations were also correlated. βig-h3 is detected in the urine specimen from women with preeclampsia and it is highly correlated to nephrin and podocalyxin concentrations in preeclampsia. βig-h3 was undetectable in normal pregnancy and pregnancy complicated with chronic hypertension. Elevated VEGF levels were also found in women with preeclampsia compared to those of normal pregnancy and pregnancy complicated with chronic hypertension. These results provide strong evidence that podocyte protein shedding occurs in preeclampsia and their levels are associated with proteinuria. The finding of urinary βig-h3 excretion in preeclampsia suggests that increased transforming growth factor activity might also be involved in the kidney lesion in this pregnancy disorder. |
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Authors:
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Yuping Wang; Shuang Zhao; Susan Loyd; Lynn J Groome |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-1 |
Journal Detail:
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Title: American journal of physiology. Renal physiology Volume: - ISSN: 1522-1466 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1LSUHSC-Shreveport. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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