| Increased urinary excretion of carnitine and acylcarnitine by mercuric chloride is reversed by 2,3-dimercapto-1-propanesulfonic acid in rats. | |
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MedLine Citation:
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PMID: 20448264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This investigation was aimed to study the effect of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on mercuric chloride (HgCl(2))-induced alterations in urinary excretion of various carnitine fractions including free carnitine (FC), acylcarnitine (AC), and total carnitine (TC). Different groups of Wistar male rats were treated with HgCl(2) at the doses of 0.1, 0.5, 1.0, 2.0, and 3.0 mg/kg body weight, and the animals were sacrificed at 24 hours following HgCl(2) injection. A separate batch of animals received HgCl(2) (2 mg/kg) with or without DMPS (100 mg/kg) and sacrificed at 24 or 48 hours after dosing. Administration of HgCl(2) resulted in statistically significant and dose-dependent increase in the urinary excretion of FC, AC, and TC in rats. However, the ratio of urinary AC:FC was significantly decreased by HgCl(2). Pretreatment with DMPS offered statistically significant protection against HgCl(2)-induced alterations in various urinary carnitine fractions in rats. |
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Authors:
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Waleed A Al-Madani; Nikhat J Siddiqi; Abdullah S Alhomida; Haseeb A Khan; Ibrahim A Arif; Uday Kishore |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of toxicology Volume: 29 ISSN: 1092-874X ISO Abbreviation: Int. J. Toxicol. Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-08-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 313-7 Citation Subset: IM |
Affiliation:
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College of Science, King Saud University, Riyadh, Saudi Arabia. khan_haseeb@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Antidotes / pharmacology*, therapeutic use Biological Markers / urine Carnitine / analogs & derivatives*, urine* Chelating Agents / pharmacology*, therapeutic use Chelation Therapy Dose-Response Relationship, Drug Hazardous Substances / toxicity* Kidney Diseases / chemically induced, drug therapy, urine Male Mercuric Chloride / toxicity* Rats Rats, Wistar Time Factors Unithiol / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antidotes; 0/Biological Markers; 0/Chelating Agents; 0/Hazardous Substances; 0/acylcarnitine; 4076-02-2/Unithiol; 541-15-1/Carnitine; 7487-94-7/Mercuric Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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