Document Detail

Increased urinary excretion of biopyrrins, oxidative metabolites of bilirubin, in patients with schizophrenia.
MedLine Citation:
PMID:  17719094     Owner:  NLM     Status:  MEDLINE    
During periods of psychological stress, excess amounts of free radicals are produced, and they play an important role in the pathophysiological process. Bilirubin oxidative metabolites, biopyrrins, are generated from bilirubin as a result of this scavenging action against free radicals. We investigated whether the urinary excretion of biopyrrin is altered during the psychotic state in patients with schizophrenia. Biopyrrin concentrations in urine of 15 patients with schizophrenia and 100 age-matched healthy subjects were measured by enzyme-linked immunosorbent assay with an anti-bilirubin antibody. Urine samples were obtained from the patients on first admission (acute state), 1 month after admission (sub-acute state), and on discharge (remission state). Urinary concentrations of biopyrrins in patients with schizophrenia on admission were significantly higher than those in the controls. Response to treatment was associated with a significant decrease in the concentrations of biopyrrins. Moreover, urinary concentrations of biopyrrins were still significantly higher in patients with schizophrenia in the sub-acute and remission states than in the controls. These results demonstrated an increase in urinary biopyrrins in patients with schizophrenia and a decrease with recovery from the psychotic state. These findings indicate that the urinary biopyrrin level is a possible indicator that can be useful in the continuous monitoring of psychotic states in clinical practice.
Rei Yasukawa; Tsuyoshi Miyaoka; Hideaki Yasuda; Maiko Hayashida; Takuji Inagaki; Jun Horiguch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-24
Journal Detail:
Title:  Psychiatry research     Volume:  153     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-15     Completed Date:  2008-02-19     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Department of Psychiatry, Shimane University School of Medicine, 89-1 Enyacho, Izumo 693-8501, Japan.
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MeSH Terms
Bilirubin / urine*
Enzyme-Linked Immunosorbent Assay
Middle Aged
Oxidative Stress
Reactive Oxygen Species
Schizophrenia / urine*
Reg. No./Substance:
0/Reactive Oxygen Species; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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