Document Detail


Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia.
MedLine Citation:
PMID:  20423563     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A compound identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) was found in higher concentrations in urine samples of children with autism compared to age and sex appropriate controls and in an adult with recurrent diarrhea due to Clostridium difficile infections. The highest value measured in urine samples was 7500 mmol/mol creatinine, a value 300 times the median normal adult value, in a patient with acute schizophrenia during an acute psychotic episode. The psychosis remitted after treatment with oral vancomycin with a concomitant marked decrease in HPHPA. The source of this compound appears to be multiple species of anaerobic bacteria of the Clostridium genus. The significance of this compound is that it is a probable metabolite of m-tyrosine (3-hydroxyphenylalanine), a tyrosine analog which depletes brain catecholamines and causes symptoms of autism (stereotypical behavior, hyperactivity, and hyper-reactivity) in experimental animals.
Authors:
William Shaw
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  13     ISSN:  1476-8305     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  135-43     Citation Subset:  IM    
Affiliation:
The Great Plains Laboratory, Inc., Lenexa, Kansas 66214, USA. williamsha@aol.com
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Autistic Disorder / urine*
Child
Child, Preschool
Clostridium / metabolism
Clostridium Infections / complications,  drug therapy
Clostridium difficile
Enterocolitis, Pseudomembranous / microbiology,  urine
Female
Gastrointestinal Tract / microbiology*
Humans
Male
Middle Aged
Phenylalanine / metabolism
Phenylpropionates / urine*
Schizophrenia / complications,  urine*
Sex Characteristics
Vancomycin / therapeutic use
Young Adult
Chemical
Reg. No./Substance:
0/Phenylpropionates; 1404-90-6/Vancomycin; 3247-75-4/3-(3-hydroxyphenyl)-3-hydroxypropanoic acid; 63-91-2/Phenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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