| Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia. | |
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MedLine Citation:
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PMID: 20423563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A compound identified as 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA) was found in higher concentrations in urine samples of children with autism compared to age and sex appropriate controls and in an adult with recurrent diarrhea due to Clostridium difficile infections. The highest value measured in urine samples was 7500 mmol/mol creatinine, a value 300 times the median normal adult value, in a patient with acute schizophrenia during an acute psychotic episode. The psychosis remitted after treatment with oral vancomycin with a concomitant marked decrease in HPHPA. The source of this compound appears to be multiple species of anaerobic bacteria of the Clostridium genus. The significance of this compound is that it is a probable metabolite of m-tyrosine (3-hydroxyphenylalanine), a tyrosine analog which depletes brain catecholamines and causes symptoms of autism (stereotypical behavior, hyperactivity, and hyper-reactivity) in experimental animals. |
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Authors:
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William Shaw |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutritional neuroscience Volume: 13 ISSN: 1476-8305 ISO Abbreviation: Nutr Neurosci Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 135-43 Citation Subset: IM |
Affiliation:
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The Great Plains Laboratory, Inc., Lenexa, Kansas 66214, USA. williamsha@aol.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Autistic Disorder / urine* Child Child, Preschool Clostridium / metabolism Clostridium Infections / complications, drug therapy Clostridium difficile Enterocolitis, Pseudomembranous / microbiology, urine Female Gastrointestinal Tract / microbiology* Humans Male Middle Aged Phenylalanine / metabolism Phenylpropionates / urine* Schizophrenia / complications, urine* Sex Characteristics Vancomycin / therapeutic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Phenylpropionates; 1404-90-6/Vancomycin; 3247-75-4/3-(3-hydroxyphenyl)-3-hydroxypropanoic acid; 63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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