Document Detail

Increased ureagenesis and impaired nitrogen use during infusion of a synthetic amino acid formula: a controlled trial.
MedLine Citation:
PMID:  6801516     Owner:  NLM     Status:  MEDLINE    
In a controlled trial conducted to assess the biologic value of High Nitrogen Vivonex, we compared this "elemental" diet with predigested protein--Product MJ7041--and with solid food during eight-day balance periods. Each formula was evaluated in three patients with malabsorption and one without it, by measuring apparent absorption of nitrogen and energy, nitrogen balance, and blood and urinary urea nitrogen. Overall energy and nitrogen absorption in the patients with malabsorption was better with either special diet than with solid food; net intestinal uptake of Vivonex tended to be higher but not consistently so in al patients. However, nitrogen balance differed consistently during the three diets; with solid food and MJ7041, retention of absorbed nitrogen was respectively, nine and 16 times greater than with Vivonex. Moreover, institution of each Vivonex period led to a prompt increase in urea nitrogen--a trend quickly reversed by the alternative diets. Although the mechanism for the impairment of nitrogen use caused by High Nitrogen Vivonex is unknown, its low biologic value and tendency to cause azotemia should be kept in mind.
J L Smith; C Arteaga; S B Heymsfield
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  306     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1013-8     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acids / administration & dosage*,  metabolism
Amino Acids, Essential / administration & dosage,  metabolism
Blood Urea Nitrogen
Clinical Trials as Topic
Energy Metabolism
Food Additives
Food, Formulated*
Intestinal Absorption
Malabsorption Syndromes / metabolism
Middle Aged
Nitrogen / metabolism*
Organic Chemicals
Parenteral Nutrition*
Parenteral Nutrition, Total*
Urea / biosynthesis*
Uremia / etiology
Grant Support
Reg. No./Substance:
0/Amino Acids; 0/Amino Acids, Essential; 0/Food Additives; 0/Organic Chemicals; 57-13-6/Urea; 7727-37-9/Nitrogen; 93197-02-5/Vivonex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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