Document Detail

Increased uptake of actinomycin D in Ehrlich ascites tumour cells induced by daunorubicin.
MedLine Citation:
PMID:  6831629     Owner:  NLM     Status:  MEDLINE    
The influence of anthracyclines on the uptake of actinomycin D in Ehrlich ascites tumour cells was studied in vitro. The anthracycline daunorubicin significantly increased the [3H]actinomycin D uptake both in whole tumour cells and in isolated nuclei of tumour cells. On the other hand, actinomycin D increased daunorubicin uptake only to a very small degree. Experiments with other intercalating drugs did not influence [3H]actinomycin D binding, suggesting a specific interaction between actinomycin D and the anthracyclines. The mechanism behind this interference is discussed. The increased cellular uptake of actinomycin D in the presence of daunorubicin may have implications for antineoplastic combination chemotherapy.
C Lund-Andersen; T Skovsgaard; N I Nissen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cancer chemotherapy and pharmacology     Volume:  10     ISSN:  0344-5704     ISO Abbreviation:  Cancer Chemother. Pharmacol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806519     Medline TA:  Cancer Chemother Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
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MeSH Terms
Carcinoma, Ehrlich Tumor / drug therapy,  metabolism*
Cell Nucleus / metabolism
Cells, Cultured
Dactinomycin / metabolism*
Daunorubicin / pharmacology*
Dose-Response Relationship, Drug
Drug Interactions
Drug Therapy, Combination
Neoplasm Transplantation
Neoplasms, Experimental / metabolism
Reg. No./Substance:
20830-81-3/Daunorubicin; 50-76-0/Dactinomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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