Document Detail


Increased uptake of 99Tcm-ethyl cysteinate dimer in patients with brain tumours.
MedLine Citation:
PMID:  11388567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed 229 99Tcm-ethyl cysteinate dimer (ECD) single photon emission tomography (SPET) studies in 185 patients with brain tumour. Increased uptake of the tracer was observed in 11 cases. In six of these 11 patients, focal intense activity was seen in the area surrounding the tumour. Five of these six patients had episodes of seizure, and ictal SPET showed further increased uptake in the area of hyperperfusion in one patient. Hyperperfusion surrounding the tumour might be related to seizure. In the remaining five patients, increased accumulation was seen in the tumour. Three of these five patients had a discrepancy between 99Tcm-ECD SPET and 201Tl SPET imaging. There could be some difference in the mechanism of accumulation in the tumour between 99Tcm-ECD and 201Tl.
Authors:
Y Ogawa; R Hashmi; A Aziz; M Ochi; K Hayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  22     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-04     Completed Date:  2001-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  479-83     Citation Subset:  IM    
Affiliation:
Department of Radiology, Nagasaki University School of Medicine, Sakamoto, Japan. yoogawa@net.nagasaki-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Astrocytoma / radionuclide imaging,  surgery
Brain / metabolism,  radionuclide imaging
Brain Neoplasms / metabolism,  radionuclide imaging*,  secondary,  surgery
Cysteine / analogs & derivatives,  diagnostic use,  pharmacokinetics*
Female
Glioblastoma / radionuclide imaging
Humans
Infant
Male
Meningioma / radionuclide imaging,  surgery
Middle Aged
Neoplasm Recurrence, Local / radionuclide imaging
Oligodendroglioma / radionuclide imaging,  surgery
Organotechnetium Compounds / diagnostic use,  pharmacokinetics*
Radiopharmaceuticals / diagnostic use,  pharmacokinetics*
Tomography, Emission-Computed, Single-Photon*
Chemical
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m bicisate; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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