Document Detail


Increased training loads do not magnify cancellous bone gains with rodent jump resistance exercise.
MedLine Citation:
PMID:  20930128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study sought to elucidate the effects of a low- and high-load jump resistance exercise (RE) training protocol on cancellous bone of the proximal tibia metaphysis (PTM) and femoral neck (FN). Sprague-Dawley rats (male, 6 mo old) were randomly assigned to high-load RE (HRE; n = 16), low-load RE (LRE; n = 15), or sedentary cage control (CC; n = 11) groups. Animals in the HRE and LRE groups performed 15 sessions of jump RE during 5 wk of training. PTM cancellous volumetric bone mineral density (vBMD), assessed by in vivo peripheral quantitative computed tomography scans, significantly increased in both exercise groups (+9%; P < 0.001), resulting in part from 130% (HRE; P = 0.003) and 213% (LRE; P < 0.0001) greater bone formation (measured by standard histomorphometry) vs. CC. Additionally, mineralizing surface (%MS/BS) and mineral apposition rate were higher (50-90%) in HRE and LRE animals compared with controls. PTM bone microarchitecture was enhanced with LRE, resulting in greater trabecular thickness (P = 0.03) and bone volume fraction (BV/TV; P = 0.04) vs. CC. Resorption surface was reduced by nearly 50% in both exercise paradigms. Increased PTM bone mass in the LRE group translated into a 161% greater elastic modulus (P = 0.04) vs. CC. LRE and HRE increased FN vBMD (10%; P < 0.0001) and bone mineral content (∼ 20%; P < 0.0001) and resulted in significantly greater FN strength vs. CC. For the vast majority of variables, there was no difference in the cancellous bone response between the two exercise groups, although LRE resulted in significantly greater body mass accrual and bone formation response. These results suggest that jumping at minimal resistance provides a similar anabolic stimulus to cancellous bone as jumping at loads exceeding body mass.
Authors:
J M Swift; H G Gasier; S N Swift; M P Wiggs; H A Hogan; J D Fluckey; S A Bloomfield
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-10-07
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-03-25     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1600-7     Citation Subset:  IM    
Affiliation:
Department of Health and Kinesiology, MS 4243, Texas A&M University, College Station, TX 77843-4243, USA.
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Animals
Bone Density
Bone Resorption / physiopathology,  prevention & control
Calcification, Physiologic
Eating
Elastic Modulus
Femur Neck / physiology*,  radiography
Male
Osteogenesis*
Rats
Rats, Sprague-Dawley
Resistance Training*
Tibia / physiology*,  radiography
Time Factors
Tomography, X-Ray Computed
Weight Gain
Weight-Bearing

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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