Document Detail


Increased titer of anticardiolipin antibodies represents the risk for the development of ischemic brain disease in persons below 50.
MedLine Citation:
PMID:  9623354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this paper was to investigate the frequency of increased ACLA titer in patients with ischemic brain disease (IBD) and to define their clinical profile. The group consisted of 162 IBD patients of both sexes, aged 39-81 years, with 50 healthy volunteers and 23 patients with other neurological diseases as control. Increased ACLA titer (above 0.9 GPL U/l IgG and 0.5 MPL U/l IgM) was registered in 17.9% IBD patients, and more frequently in patients with transitory ischemic attacks (TIA)-32.6%; slightly increased titer predominated (0.9-20 GPL U/l IgG and 0.5-15 MPL U/l IgM) in 69% IBD patients, while moderately increased (20-80 GPL U/l and 15-50 MPL U/l IgM) was present in 21% IBD patients, while highly increased titer (above 80 GPL U/l IgG and above 50 MPL U/l IgM) was present in 10.3%; IgG class was most frequently increased (9.2%), than IgM-5%, while increase of both classes was present in 3.7%. All patients with increased ACLA titer were below 50 years of age, had history of previous IBD attacks, more often TIA, irregularity of at least one coagulation test and fewer risk factors for IBD. Hence, increased ACLA titer was present in IBD patients of both sexes, below 50 years of age with previous history of IBD attacks and fewer atherosclerosis risk factors.
Authors:
D Dordević; A Jovicić; V Regović; R Raicević
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vojnosanitetski pregled. Military-medical and pharmaceutical review     Volume:  55     ISSN:  0042-8450     ISO Abbreviation:  Vojnosanit Pregl     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-08-24     Completed Date:  1998-08-24     Revised Date:  2008-01-09    
Medline Journal Info:
Nlm Unique ID:  21530700R     Medline TA:  Vojnosanit Pregl     Country:  YUGOSLAVIA    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
Affiliation:
Military Medical Academy, Department of Neurology, Belgrade.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Aged, 80 and over
Antibodies, Anticardiolipin / blood*
Cerebral Infarction / diagnosis,  immunology
Female
Humans
Ischemic Attack, Transient / diagnosis*,  immunology
Male
Middle Aged
Risk Factors
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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