Document Detail

Increased tissue thromboplastin activity in monocytes of patients with meningococcal infection: related to an unfavourable prognosis.
MedLine Citation:
PMID:  6845273     Owner:  NLM     Status:  MEDLINE    
In 16 patients, 13 with meningococcal infection and 3 suspected to have this infection, 8 patients were found to possess significant higher level of tissue thromboplastin activity of their monocytes isolated from the blood at the admission to the hospital than normal. Five of those 8 patients had an extremely high concentration, greater than 60-300 fold increase, and all these patients died. The exposed tissue thromboplastin activity on the surface of the endotoxin stimulated monocytes is probably the direct inducer of disseminated intravascular coagulation (DIC) in meningococcal infection.
B Osterud; T Flaegstad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  49     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  5-7     Citation Subset:  IM    
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MeSH Terms
Blood Cell Count
Child, Preschool
Meningococcal Infections / blood*,  microbiology
Monocytes / metabolism*
Thromboplastin / metabolism*
Time Factors
Reg. No./Substance:

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