| Increased tissue factor pathway inhibitor in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 9257877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined hemostatic abnormalities in 23 patients with acute myocardial infarction (AMI), 10 with pulmonary embolism (PE), and 10 with deep vein thrombosis (DVT). At the onset of AMI, plasma levels of tissue-type plasminogen activator (t-PA), PA inhibitor-I (PAI-I), fibrin-D-dimer, thrombin-antithrombin complex (TAT), and plasmin-plasmin inhibitor complex (PPIC) were significantly increased. Both the plasma total TFPI and free-TFPI levels in the AMI patients were significantly higher than those in the healthy volunteers, PE patients, and DVT patients. There was no significant difference in total TFPI or free-TFPI among patients with PE, those with DVT, and healthy volunteers. One hour after percutaneous transluminal coronary angioplasty (PTCA) in the AMI group, the total TFPI level was further increased, and it was significantly reduced 24 hr after PTCA, to a level similar to that in healthy volunteers. Free-TFPI showed a pattern similar to that of total TFPI. The ratio of free-TFPI/total TFPI was highest 1 hr after PTCA. Increased TFPI in AMI patients might be released from ischemic tissues. |
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Authors:
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Y Kamikura; H Wada; A Yamada; M Shimura; K Hiyoyama; H Shiku; M Tanigawa; H Nishikawa; N Yamada; N Isaka; T Nakano; K Kumeda; H Kato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of hematology Volume: 55 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-03 Completed Date: 1997-09-03 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 183-7 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Mie University School of Medicine, Tsu-city, Mie-ken, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angioplasty, Transluminal, Percutaneous Coronary Antifibrinolytic Agents / analysis, blood Antithrombin III / analysis Female Fibrin Fibrinogen Degradation Products / analysis Fibrinolysin / analysis Humans Lipoproteins / blood* Male Middle Aged Myocardial Infarction / blood* Peptide Hydrolases / analysis Plasminogen Activator Inhibitor 1 / blood Pulmonary Embolism / blood Thrombosis / blood Tissue Plasminogen Activator / blood alpha-2-Antiplasmin* |
| Chemical | |
Reg. No./Substance:
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0/Antifibrinolytic Agents; 0/Fibrin Fibrinogen Degradation Products; 0/Lipoproteins; 0/Plasminogen Activator Inhibitor 1; 0/alpha-2-Antiplasmin; 0/antithrombin III-protease complex; 0/fibrin fragment D; 0/lipoprotein-associated coagulation inhibitor; 0/plasmin-plasmin inhibitor complex; 9000-94-6/Antithrombin III; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.7/Fibrinolysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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