Document Detail

Increased sympathetic nervous system activity as cause of exercise-induced ventricular tachycardia in patients with normal coronary arteries.
MedLine Citation:
PMID:  12809249     Owner:  NLM     Status:  MEDLINE    
In this prospective study, we set out to determine whether analysis of heart rate variability (HRV) in patients with exercise-induced ventricular tachycardia (EIVT) and normal coronary arteries would reveal increased sympathetic nervous system activity. From January 1996 to December 2001, we compared 16 patients with EIVT and normal coronary arteries with an age- and sex-matched control group. Analysis of HRV showed that parameters indicative of parasympathetic activity were lower in our study group than in our control group: standard deviation of the mean of qualified NN intervals (SDNN), 81.6 +/- 14.5 vs 139.3 +/- 11.0, P <0.001; root mean square of successive differences (RMSSD), 22.3 +/- 4.8 vs 36.3 +/- 6.6, P <0.001; number of NN intervals that differed by more than 5 ms from the adjacent interval, divided by the total number of NN intervals (PNN50), 4.8 +/- 1.5 vs 10.2 +/- 3. 1, P <0.001; and high-frequency component (HF), 28.7 +/- 2.5 vs 32.4 +/- 3.9, P <0.05. Conversely, parameters indicative of sympathetic activity were higher in patients with EIVT: low-frequency component (LF), 71.2 +/- 5.0 vs 52.0 +/- 5.8, P <0.001; and absolute low/high frequency component ratio (LF/HF), 2.7 +/- 0.2 vs 1.6 +/- 0.2, P <0.001. There was a positive correlation between EIVT and LF (r=0.79, P <0.001) and between EIVT and LF/HF (r=0.81, P <0.001). Our results suggest the presence of increased sympathetic and decreased parasympathetic tone in patients with EIVT. We conclude that EIVT is associated with an imbalance in the autonomic nervous system.
Ozcan Ozdemir; Mustafa Soylu; Ahmet Duran Demir; Serkan Topaloglu; Omer Alyan; Bilal Geyik; Emine Kutuk
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  30     ISSN:  0730-2347     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2003  
Date Detail:
Created Date:  2003-06-17     Completed Date:  2003-10-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-4     Citation Subset:  IM    
Cardiology Clinics, Turkiye Yuksek Ihtisas Hospital, Sihhiye, Ankara, Turkey.
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MeSH Terms
Exercise Test
Heart Rate
Middle Aged
Parasympathetic Nervous System / physiopathology
Prospective Studies
Sympathetic Nervous System / physiopathology*
Tachycardia, Ventricular / etiology,  physiopathology*

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