Document Detail


Increased susceptibility to malaria during the early postpartum period.
MedLine Citation:
PMID:  10965006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pregnancy is associated with increased susceptibility to malaria. It is generally agreed that this increased risk ends with delivery, but the possible persistence of increased susceptibility during the puerperium had not been investigated. METHODS: From June 1, 1990, to December 31, 1998, we monitored exposure to malaria, parasitemia, and morbidity among the residents of a village in Senegal in which the rate of transmission of malaria was high. In this population we analyzed 71 pregnancies in 38 women from the year before conception and through one year after delivery. RESULTS: Among the 38 women, there were 58 episodes of clinical Plasmodium falciparum malaria during 61,081 person-days of observation. The incidence of malaria was 20.2 episodes per 1000 person-months during the year preceding conception and 12.0 episodes per 1000 person-months during the period from 91 to 365 days after delivery. The incidence of episodes of malaria increased significantly during the second and third trimesters of pregnancy and reached a maximum of 75.1 episodes per 1000 person-months during the first 60 days after delivery. The adjusted relative risk of an episode of malaria was 4.1 (95 percent confidence interval, 1.8 to 9.5) during the first 60 days post partum, as compared with the year preceding pregnancy. The duration of fever during the episodes of malaria was longer and the prevalence and density of asymptomatic malarial parasitemia were significantly higher during pregnancy and the early postpartum period than during the other periods. CONCLUSIONS: Among women who live in areas with high rates of transmission of malaria, the susceptibility to malaria is highest during the second and third trimesters of pregnancy and the early postpartum period.
Authors:
N Diagne; C Rogier; C S Sokhna; A Tall; D Fontenille; C Roussilhon; A Spiegel; J F Trape
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  343     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-06     Completed Date:  2000-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  598-603     Citation Subset:  AIM; IM; J    
Affiliation:
Laboratoire de Paludologie, Institut de Recherche pour le Développement, Dakar, Senegal.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Disease Susceptibility
Female
Humans
Incidence
Longitudinal Studies
Malaria, Falciparum / diagnosis,  epidemiology*
Morbidity
Parasitemia / diagnosis,  epidemiology
Plasmodium falciparum / isolation & purification
Poisson Distribution
Postpartum Period*
Pregnancy
Pregnancy Complications, Infectious / diagnosis,  epidemiology*
Risk Factors
Senegal / epidemiology
Comments/Corrections
Comment In:
N Engl J Med. 2000 Aug 31;343(9):651-2   [PMID:  10965013 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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