Document Detail


Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury.
MedLine Citation:
PMID:  23150232     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Our data revealed a novel role of NKT cells in regulating responses to starvation-induced metabolic stress. Elevated ketone body production in NKT cell-deficient mice resulted in increased CYP2E1-mediated APAP biotransformation and susceptibility to AILI.
Authors:
Brittany V Martin-Murphy; Douglas J Kominsky; David J Orlicky; Terrence M Donohue; Cynthia Ju
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-18
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-07-05     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1575-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / adverse effects*
Animals
Antigens, CD1d / genetics,  metabolism
Cytochrome P-450 CYP2E1 / metabolism
Disease Models, Animal
Disease Susceptibility / pathology*
Drug-Induced Liver Injury / metabolism,  pathology*
Female
Glutathione / metabolism
Ketone Bodies / metabolism
Liver / metabolism,  pathology
Lymphopenia / genetics,  pathology*
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Natural Killer T-Cells / immunology,  pathology*
Reactive Oxygen Species / metabolism
Grant Support
ID/Acronym/Agency:
F31 DK082269/DK/NIDDK NIH HHS; F31DK082269/DK/NIDDK NIH HHS; R01ES012914/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD1d; 0/Ketone Bodies; 0/Reactive Oxygen Species; 362O9ITL9D/Acetaminophen; EC 1.14.14.1/Cytochrome P-450 CYP2E1; GAN16C9B8O/Glutathione
Comments/Corrections

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