| Increased survival of rats bearing Morris hepatoma 7800 after induction of hypothyroidism. | |
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MedLine Citation:
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PMID: 445436 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The survival of Buffalo rats brearing Morris Hepatoma 7800 was increased significantly (23 to 31%) after induction of hypothyroidism by propylthiouracil (PTU) (0.1% in Purina rat chow) or 131I. The concentration of PTU used was in the optimal range as 0.03% PTU was less effective than 0.1%, while 0.4% PTU appeared to be toxic. Exogenous thyroxine (8 microgram/kg body weight) reversed the effects of PTU and actually shortened survival. Because food consumption and body weights of hypothyroid rats were decreased, the survival of pair-fed controls was studied and found to be the same as in untreated controls. We conclude that the hypothyroid state increases the survival of rats bearing Morris Hepatoma 7800. We have not yet been able to define any anatomical or biochemical parameters which may be responsible for this effect. |
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Authors:
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S Mishkin; H P Morris; M A Yalovsky; P V Narasimha Murthy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cancer research Volume: 39 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1979 Jul |
Date Detail:
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Created Date: 1979-09-01 Completed Date: 1979-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2371-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Hypothyroidism / physiopathology* Liver Neoplasms, Experimental / etiology*, pathology Neoplasms, Hormone-Dependent Organ Size Propylthiouracil / administration & dosage, pharmacology Rats Thyroid Gland / physiology Thyroxine / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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51-52-5/Propylthiouracil; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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