Document Detail

Increased survival of low birth weight infants: impact on the incidence of retinopathy of prematurity.
MedLine Citation:
PMID:  2788864     Owner:  NLM     Status:  MEDLINE    
Retinopathy of prematurity is a retinal vascular disease that occurs only in premature infants. Because of concern that the occurrence of this potentially blinding disease is increasing, a retrospective chart review was undertaken to compare the incidence of retinopathy of prematurity at the University of Washington during the years 1981 to 1984 with previously published data collected at the same institution during the years 1968 to 1980. During 1981 to 1984, there was an increase in the annual numbers of admissions and survivors weighing 1750 g at birth; the survival rate increased significantly (P less than .000001). A trend toward an increased risk for proliferative retinopathy of prematurity (P = .057) during 1981 to 1984 period was noted, but the number of "excess cases" was calculated to be only 6 per year. The remainder of the additional cases, 19 annually, were due to increased survival of infants at risk. Thus, the "second epidemic" of retinopathy of prematurity is largely due to improved survival of low birth weight infants rather than to new iatrogenic factors. In infants with proliferative retinopathy of prematurity, there was a previously unreported association between increased severity of disease and lower birth weight (P = .015). There were four children with severe bilateral visual loss due to retinopathy of prematurity identified during the 1981 to 1984 period, whereas only one bilaterally blind infant was noted during the preceding 12.7 years.
P H Valentine; J C Jackson; R E Kalina; D E Woodrum
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  84     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-09-28     Completed Date:  1989-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  442-5     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Washington School of Medicine, Seattle 98195.
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MeSH Terms
Birth Weight
Blindness / epidemiology
Cohort Studies
Infant, Low Birth Weight*
Infant, Newborn
Retinopathy of Prematurity / epidemiology*
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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