| Increased survival by feeding tetradecylthioacetic acid during a natural outbreak of heart and skeletal muscle inflammation in S0 Atlantic salmon, Salmo salar L. | |
| | |
MedLine Citation:
|
PMID: 19602091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have previously documented increased survival by feeding tetradecylthioacetic acid (TTA) during a natural outbreak of infectious pancreatic necrosis in post-smolt S1 Atlantic salmon. The aim of the present study was to test the effects of dietary TTA in S0 smolt at a location where fish often experience natural outbreaks of heart and skeletal muscle inflammation (HSMI) during their first spring at sea. The experimental groups were fed a diet supplemented with 0.25% TTA for a 6-week period prior to a natural outbreak of HSMI in May 2007. Relative percent survival for the groups fed TTA was 45% compared with control diets, reducing mortality from 4.7% to 2.5%. Expression of genes related to lipid oxidation was higher in cardiac ventricles from salmon fed TTA compared with controls. In addition, salmon fed TTA had periodically reduced levels of plasma urea, and increased cardiosomatic index and growth. Reduced mortality and increased growth after administration of TTA may be related to a combination of anti-inflammatory effects, and an altered metabolic balance with better protein conservation because of increased lipid degradation. |
| | |
Authors:
|
H Alne; M S Thomassen; H Takle; B F Terjesen; F Grammes; M Oehme; S Refstie; T Sigholt; R K Berge; K-A R??rvik |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-10 |
Journal Detail:
|
Title: Journal of fish diseases Volume: 32 ISSN: 1365-2761 ISO Abbreviation: J. Fish Dis. Publication Date: 2009 Nov |
Date Detail:
|
Created Date: 2009-10-21 Completed Date: 2009-12-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9881188 Medline TA: J Fish Dis Country: England |
Other Details:
|
Languages: eng Pagination: 953-61 Citation Subset: IM |
Affiliation:
|
NOFIMA, As, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Body Weight / drug effects Fatty Acids / therapeutic use* Fish Diseases / drug therapy*, mortality Gene Expression Regulation / drug effects Heart / drug effects Lipid Metabolism / drug effects Muscle, Skeletal / drug effects, pathology Myocarditis / drug therapy, mortality, veterinary* Myocardium / pathology Myositis / drug therapy, mortality, veterinary* Random Allocation Salmo salar / physiology* Sulfides / pharmacology, therapeutic use* Survival Analysis Urea / blood |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 0/Sulfides; 2921-20-2/1-(carboxymethylthio)tetradecane; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development and characterization of a monoclonal antibody against Taura syndrome virus.
Next Document: Melanomacrophages in three species of free-ranging sharks from the northwestern Atlantic, the blue s...