Document Detail

Increased survival after cecal ligation and puncture in mice consuming diets enriched with sesame seed oil.
MedLine Citation:
PMID:  11176174     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Lignans that present in the nonfat portion of sesame seed oil (SSO) can inhibit delta-5 desaturase activity, resulting in an increase in the accumulation of dihomo-gamma-linolenic acid and, subsequently, decrease the production of proinflammatory dienoic eicosanoids with a concomitant increase in the secretion of less inflammatory monoenoic eicosanoids. DESIGN: Female Balb/c mice were fed diets supplemented with 5wt% SSO or a physical mixture of oils (control) whose fatty acid composition resembled that of SSO for 3 wks. MEASUREMENTS AND MAIN RESULTS: During a 4-day observation period after cecal ligation and puncture, only 20% of the controls and as many as 65% in the SSO group survived. Furthermore, the levels of cytokines and dienoic eicosanoids produced in response to an intraperitoneal injection of a nonlethal dose (50 microg/mouse) of endotoxin were measured in both groups. The interleukin (IL)-10 levels were markedly higher in mice fed SSO diets compared with the controls. However, the plasma concentrations of prostaglandin E1 + 2, tumor necrosis factor-alpha, IL-6, and IL-12 did not differ significantly between the two groups of mice. CONCLUSIONS: Because the fatty acid composition is almost similar between the two diets, sesamin, sesamol and other lignans in SSO appear to be responsible for an increase in survival after cecal ligation and puncture and also for an increase in the IL-10 levels in response to a nonlethal dose of endotoxin in mice.
S R Chavali; T Utsunomiya; R A Forse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  29     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-25     Completed Date:  2001-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  140-3     Citation Subset:  AIM; IM    
Department of Surgery, Harvard Institutes of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Cecum / injuries
Cytokines / immunology,  metabolism*
Dietary Supplements*
Dinoprostone / blood
Interleukin-10 / blood
Interleukin-6 / blood
Lignans / immunology
Mice, Inbred BALB C
Sesame Oil*
Shock, Septic / immunology*,  mortality*
Statistics, Nonparametric
Survival Rate
Tumor Necrosis Factor-alpha / metabolism
Wounds, Penetrating / complications
Reg. No./Substance:
0/Cytokines; 0/Interleukin-6; 0/Lignans; 0/Lipopolysaccharides; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 363-24-6/Dinoprostone; 8008-74-0/Sesame Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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