| Increased surveillance of cells in mitosis by human NK cells suggests a novel strategy for limiting tumor growth and viral replication. | |
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MedLine Citation:
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PMID: 16960147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The threat from cancer cells is inherently linked to cell-cycle progression, and viral genomes commonly replicate, for example, within episomes or proviruses, during mitosis. We report here that human natural killer (NK) cells bound cells in mitosis and attacked pathogenic cells in mitosis more effectively than the same cells in other stages of the cell cycle. Thus, cells in mitosis warrant and undergo heightened surveillance, a novel strategy for immunologic assessment of danger. Recognition of cells in mitosis involved ligation of activating NK-cell receptors and binding to target-cell hyaluronan, a component of the pericellular matrix known to be increased during mitosis. Direct interaction between activating NK-cell receptors and hyaluronan is possible, but other mechanisms consistent with our data are also discussed. |
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Authors:
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Esther N M Nolte-'t Hoen; Catarina R Almeida; Nadia R Cohen; Shlomo Nedvetzki; Helen Yarwood; Daniel M Davis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-07 |
Journal Detail:
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Title: Blood Volume: 109 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-09 Completed Date: 2007-08-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 670-3 Citation Subset: AIM; IM |
Affiliation:
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Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College London, SW7 2AZ, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle
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immunology Cell Line, Tumor Cells, Cultured Humans Immunologic Surveillance / immunology* Killer Cells, Natural / immunology* Mitosis / immunology* Neoplasms / immunology*, pathology Time Factors Virus Replication / immunology |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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