Document Detail

Increased structural connectivity in grapheme-color synesthesia.
MedLine Citation:
PMID:  17515901     Owner:  NLM     Status:  MEDLINE    
Diffusion tensor imaging allowed us to validate for the first time the hypothesis that hyperconnectivity causes the added sensations in synesthesia. Grapheme-color synesthetes (n = 18), who experience specific colors with particular letters or numbers (for example, 'R is sky blue'), showed greater anisotropic diffusion compared with matched controls. Greater anisotropic diffusion indicates more coherent white matter. Anisotropy furthermore differentiated subtypes of grapheme-color synesthesia. Greater connectivity in the inferior temporal cortex was particularly strong for synesthetes who see synesthetic color in the outside world ('projectors') as compared with synesthetes who see the color in their 'mind's eye' only ('associators'). In contrast, greater connectivity (as compared with non-synesthetes) in the superior parietal or frontal cortex did not differentiate between subtypes of synesthesia. In conclusion, we found evidence that increased structural connectivity is associated with the presence of grapheme-color synesthesia, and has a role in the subjective nature of synesthetic color experience.
Romke Rouw; H Steven Scholte
Publication Detail:
Type:  Journal Article     Date:  2007-05-21
Journal Detail:
Title:  Nature neuroscience     Volume:  10     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-25     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  792-7     Citation Subset:  IM    
Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018WB Amsterdam, The Netherlands.
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MeSH Terms
Brain Mapping
Cerebral Cortex / anatomy & histology,  physiology*
Color Perception / physiology*
Diffusion Magnetic Resonance Imaging
Field Dependence-Independence
Pattern Recognition, Visual / physiology
Reaction Time / physiology
Visual Pathways / anatomy & histology,  physiology*
Comment In:
Nat Neurosci. 2007 Jun;10(6):671-2   [PMID:  17525757 ]

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