Document Detail

Increased striatal expression of glutamate decarboxylase 67 after priming of 6-hydroxydopamine-lesioned rats.
MedLine Citation:
PMID:  10362306     Owner:  NLM     Status:  MEDLINE    
Previous single exposure (priming) to a dopamine receptor agonist greatly enhances the contralateral turning behaviour elicited by dopamine D1 receptor agonists in unilaterally 6-hydroxydopamine lesioned rats. In the present study we have investigated the levels of glutamate decarboxylase 67 and glutamate decarboxylase 65 messenger RNA in the striatum of 6-hydroxydopamine-lesioned rats primed with L-3,4-dihydroxyphenylalanine (L-DOPA) and challenged with the D1 receptor agonist SKF 38393, three days thereafter. As previously reported, levels of glutamate decarboxylase 67 messenger RNA increased in the striatum denervated by the 6-hydroxydopamine lesion as compared with the intact one. Striatal glutamate decarboxylase 67 messenger RNA levels, measured three days after priming with L-DOPA (50 mg/kg), further increased in the lesioned striatum while were not modified in the intact one. Administration of SKF 38393 (3 mg/kg) elicited a more intense contralateral turning behaviour in primed than in drug-naive 6-hydroxydopamine-lesioned rats but did not induce any change in striatal glutamate decarboxylase 67 messenger RNA. In contrast, striatal levels of glutamate decarboxylase 65 messenger RNA were not modified by either 6-hydroxydopamine lesions or priming with L-DOPA. The results show that priming with L-DOPA induces long-lasting changes in GABAergic neurons of the 6-hydroxydopamine-lesioned striatum. These changes might play a role in the increased behavioural response of striatal D1 receptors induced by priming.
S Consolo; M Morelli; M Rimoldi; S Giorgi; G Di Chiara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience     Volume:  89     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1999  
Date Detail:
Created Date:  1999-07-22     Completed Date:  1999-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1183-7     Citation Subset:  IM    
Mario Negri Institute of Pharmacological Research, Milano, Italy.
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MeSH Terms
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
Corpus Striatum / drug effects,  enzymology,  physiology*
Functional Laterality
Gene Expression Regulation, Enzymologic* / drug effects
Glutamate Decarboxylase / genetics*
Isoenzymes / genetics
Levodopa / pharmacology*
Motor Activity / drug effects
Neurons / drug effects,  enzymology,  physiology*
Oxidopamine / toxicity
RNA, Messenger / genetics
Rats, Sprague-Dawley
Receptors, Dopamine D1 / agonists,  physiology*
Time Factors
Transcription, Genetic* / drug effects
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Isoenzymes; 0/Levodopa; 0/RNA, Messenger; 0/Receptors, Dopamine D1; 1199-18-4/Oxidopamine; 56-12-2/gamma-Aminobutyric Acid; 67287-49-4/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; EC Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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