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Increased striatal dopamine transporter density in moderately severe old restless legs syndrome patients.
MedLine Citation:
PMID:  22435397     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and purpose:  Dopamine dysregulation in restless legs syndrome (RLS) may be varied by the severity of RLS, which could contribute to the conflicting results from previous functional neuroimaging studies on the central dopaminergic neurotransmission of RLS. The aim of this study was to observe whether reduced striatal dopaminergic neurotransmission is associated with moderate to moderately severe RLS. Methods:  Thirteen elderly patients with RLS and 12 normal elderly controls were enrolled in the study. All the subjects were dopaminergic-drug naïve and twelve patients with RLS had the severity of moderate to moderately severe degree based on the International Restless Legs Syndrome Study Group (IRLSSG) Severity Scale. We compared dopamine transporter density (DAT) availability and D2 receptor density in the striatum between patients with RLS and controls using [(123) I]2β-carbomethoxy-3β-(4-iodophenyl)tropane single-photon emission computed tomography (SPECT) and [(123) I]iodobenzamide SPECT. Results:  Dopamine transporter density of patients with RLS was increased in the caudate (P = 0.037), posterior putamen (P = 0.041), and entire striatum (P = 0.046) compared with that of normal controls. DAT density was higher in the anterior putamen of patients with RLS than controls, although statistically not significant (P = 0.079). There was no difference in the D2 receptor density between patients with RLS and normal controls in the whole striatum or any of subregions. Conclusions:  Dysregulation rather than simple upregulation or downregulation of central dopaminergic neurotransmission may underlie the pathogenesis of RLS, and decreased dopaminergic neurotransmission may cause moderate to moderately severe RLS in the elderly.
Authors:
K W Kim; J H Jhoo; S B Lee; S D Lee; T H Kim; S E Kim; Y K Kim; I-Y Yoon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-21
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  -     ISSN:  1468-1331     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author(s). European Journal of Neurology © 2012 EFNS.
Affiliation:
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggi Department of Psychiatry, Seoul National University College of Medicine, Seoul Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon Department of Psychiatry, Dankook University Hospital, Cheonan Department of Nuclear Medicine, Seoul National University Bundang Hospital, Gyeonggi, Korea.
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