Document Detail


Increased arterial stiffness and extracellular matrix reorganization in intrauterine growth-restricted fetal sheep.
MedLine Citation:
PMID:  23154756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Fetal intrauterine growth restriction (IUGR) results in increased placental resistance to blood flow, fetal hypertension, and increased pulsatility stresses shown to lead to vascular remodeling. We tested our hypothesis that IUGR causes decreased compliance in the carotid and umbilical arteries due to altered extracellular matrix (ECM) composition and structure.
METHODS: A sheep model of placental insufficiency-induced IUGR (PI-IUGR) was created by exposure of the pregnant ewe to elevated ambient temperatures. Umbilical and carotid arteries from near-term fetuses were tested with pressure-diameter measurements to compare passive compliance in control and PI-IUGR tissues. ECM composition was measured via biochemical assay, and the organization was determined by using histology and second-harmonic generation imaging.
RESULTS: We found that PI-IUGR increased arterial stiffness with increased collagen engagement, or transition stretch. PI-IUGR carotid arteries exhibited increased collagen and elastin quantity, and PI-IUGR umbilical arteries exhibited increased sulfated glycosaminoglycans. Histomorphology showed altered collagen-to-elastin ratios with altered cellular proliferation. Increased stiffness indicates altered collagen-to-elastin ratios with less elastin contribution leading to increased collagen engagement.
CONCLUSION: Because vessel stiffness is a significant predictor in the development of hypertension, disrupted ECM deposition in IUGR provides a potential link between IUGR and adult hypertension.
Authors:
Reuben Blair Dodson; Paul J Rozance; Bradley S Fleenor; Carson C Petrash; Lauren G Shoemaker; Kendall S Hunter; Virginia L Ferguson
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Publication Detail:
Type:  Journal Article     Date:  2012-11-15
Journal Detail:
Title:  Pediatric research     Volume:  73     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-07     Completed Date:  2013-07-26     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-54     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, University of Colorado at Boulder, Boulder, Colorado, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carotid Arteries / metabolism,  pathology,  physiopathology*
Cell Proliferation
Collagen / metabolism
Compliance
Disease Models, Animal
Elastin / metabolism
Extracellular Matrix / metabolism,  pathology*
Female
Fetal Growth Retardation / metabolism,  pathology,  physiopathology*
Gestational Age
Glycosaminoglycans / metabolism
Hypertension / metabolism,  physiopathology
Male
Pregnancy
Sheep
Umbilical Arteries / metabolism,  pathology,  physiopathology*
Vascular Stiffness*
Grant Support
ID/Acronym/Agency:
K08 HD060688/HD/NICHD NIH HHS; K25 HL094749/HL/NHLBI NIH HHS; R01 DK088139/DK/NIDDK NIH HHS; R01 HL114887/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Glycosaminoglycans; 9007-34-5/Collagen; 9007-58-3/Elastin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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