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Increased spontaneous gamma power and synchrony in schizophrenia patients having higher minor physical anomalies.
MedLine Citation:
PMID:  23051885     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Higher frequency of minor physical anomalies (MPAs) in schizophrenia provides morphological evidence for the neurodevelopmental theory. Abnormal gamma oscillations (>30Hz) seen in schizophrenia have been hypothesized to result from developmental insults. This study investigated spontaneous gamma oscillations in schizophrenia patients having higher and lower number of MPAs. Forty drug naïve/free schizophrenia patients and 20 matched healthy controls were assessed for MPAs on the Extended Waldrop Scale (EWS). All participants underwent an awake, resting 192-channel EEG recording. Spontaneous gamma spectral power and coherence were estimated in the low- (30-50Hz) and high-gamma (51-70 and 71-100Hz) bands. Significantly higher power was observed in high-MPA than healthy control group in low-gamma band over right frontal, parietal and temporal regions. Spectral power in the high-gamma band (71-100Hz) was also significantly higher in high-MPA than healthy control group over left frontal, parietal and temporal regions. Additionally, regional intra-hemispheric and inter-hemispheric coherence in low-gamma band was significantly higher in high-MPA than healthy control group. This study is the first to provide evidence of increased spontaneous gamma power and synchrony in schizophrenia patients having higher MPAs, supporting the idea that it may represent a distinct subgroup of schizophrenia having neurodevelopmental basis.
Authors:
Sai Krishna Tikka; Shamsul Haque Nizamie; Basudeb Das; Mohammad Zia Ul Haq Katshu; Nishant Goyal
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-7
Journal Detail:
Title:  Psychiatry research     Volume:  -     ISSN:  1872-7123     ISO Abbreviation:  Psychiatry Res     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi 834006, Jharkhand, India. Electronic address: cricsai@gmail.com.
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