Document Detail

Increased sodium-lithium countertransport in red cells of patients with essential hypertension.
MedLine Citation:
PMID:  7354809     Owner:  NLM     Status:  MEDLINE    
This paper describes experiments showing that one of the pathways of sodium transport across the red-cell membrane, sodium-lithium countertransport, is faster in patients with essential hypertension than in control subjects. This transport system accepts only sodium or lithium and is not inhibited by ouabain. The maximum rate of transport shows inherited differences. The mean maximum rate of sodium-lithium countertransport was found to be 0.55 +/- 0.02 (mean +/- S.E.M.) mmol (liter of red cells X hour)(-1) in a group of 36 patients with essential hypertension and 0.24 +/- 0.02 in 26 control subjects (P less than 0.001). The first-degree relatives of eight patients with essential hypertension and 10 control subjects had mean maximum rates of sodium-lithium countertransport of 0.54 +/- 0.05 and 0.23 +/- 0.02, respectively. Five patients with secondary hypertension had normal mean maximum rates of sodium-lithium countertransport. The relation between heritability of red-cell sodium-lithium countertransport and essential hypertension should be investigated further.
M Canessa; N Adragna; H S Solomon; T M Connolly; D C Tosteson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  302     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-04-25     Completed Date:  1980-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  772-6     Citation Subset:  AIM; IM    
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MeSH Terms
Biological Transport
Erythrocyte Membrane / metabolism
Erythrocytes / metabolism*
Hypertension / blood*
Lithium / blood*
Potassium / blood
Sodium / blood*
Water-Electrolyte Balance
Reg. No./Substance:
7439-93-2/Lithium; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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