Document Detail

Increased sodium concentrations in drinking water increase blood pressure in neonates.
MedLine Citation:
PMID:  11821704     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In a previous study, we found that increased sodium concentrations in the drinking water led to an increase in mean arterial pressure (MAP) and systolic blood pressure (SBP) in fourth- and fifth-grade school children. Milk powder formulae have a low content of sodium, almost identical to that of breast milk. However, the final sodium concentration in the milk formula depends upon the concentration of sodium in the diluting water, which varies remarkably. OBJECTIVE: To evaluate changes in blood pressure during the first 2 months of life in neonates receiving low-sodium mineral water (LSMW), high-sodium tap water (HSTW), or breast milk. DESIGN: A randomized, prospective study in a teaching hospital. METHODS: Fifty-eight Jewish term infants maintained on milk formula were randomly assigned to two groups. Group 1 consisted of 25 infants whose formula was diluted with LSMW (Eden Spring Mineral Water) having a sodium concentration of 32 mg/l (1.4 mmol/l). Group 2 contained 33 infants whose formula was diluted with HSTW having a sodium concentration of 196 mg/l (8.5 mmol/l). Fifteen breastfed babies served as the control group (group 3). Weekly weight, height, head circumference, heart rate, and systolic (SBP), diastolic (DBP) and mean (MAP) blood pressures were recorded for each infant for 8 consecutive weeks after birth. After 8 weeks, group 1 reverted to a diet similar to that of group 2. At 6 months of age (week 24), a follow-up blood pressure measurement was performed in 11, 20 and seven infants in groups 1, 2 and 3, respectively. Blood pressure was measured during sleep. Urinary sodium : creatinine ratio was determined monthly during the initial 2 months. RESULTS: Increases in weight and height were equal in all groups. Heart rate did not differ between groups during the entire study period. From the age of 6 weeks until week 8, MAP, SBP and DBP were found to be significantly greater in the group 2 (HSTW). In parallel, the urinary sodium : creatinine ratio was significantly greater in this group. At week 24, blood pressure values in group 1 increased towards those of group 2. CONCLUSIONS: Diluting milk formula with tap water containing a high concentration of sodium will result in the infant being fed a high-salt diet. To equilibrate with breast milk, formula should be diluted with low-salt water. Blood pressure in the neonate is increased by a high sodium intake via drinking water.
Avishalom Pomeranz; Tzipora Dolfin; Ze'ev Korzets; Alon Eliakim; Baruch Wolach
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Publication Detail:
Type:  Clinical Trial; Evaluation Studies; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension     Volume:  20     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-31     Completed Date:  2002-05-01     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM    
Unit of Pediatric Nephrology, Meir General Hospital, Sapir Medical Center, Kfar-Saba and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Blood Pressure / drug effects*,  physiology*
Follow-Up Studies
Infant Welfare
Infant, Newborn / physiology*
Israel / epidemiology
Milk, Human / chemistry,  secretion
Prospective Studies
Sodium / administration & dosage*,  analysis*
Time Factors
Water Supply / analysis*
Reg. No./Substance:

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