Document Detail

Increased sister-chromatid exchange frequency in patients receiving sulphasalazine therapy for ulcerative colitis.
MedLine Citation:
PMID:  6135986     Owner:  NLM     Status:  MEDLINE    
Sister-chromatid exchange and micronucleus frequencies are reported for lymphocytes cultured in vitro from 15 patients receiving sulphasalazine therapy for ulcerative colitis and 15 controls matched for age and sex. While the patients did not differ from matched controls for micronucleus frequency there was a substantial rise in their sister-chromatid exchange frequency. This evidence of DNA damage is discussed in relation to the known cancer risk that ulcerative colitis carries and the possibility of an increased mutation rate in the germ cells of those receiving sulphasalazine therapy.
J M Mackay; D P Fox; P W Brunt; A W Johnston
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  118     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-09-20     Completed Date:  1983-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking
Cell Nucleus / drug effects
Cells, Cultured
Colitis, Ulcerative
Crossing Over, Genetic / drug effects*
Lymphocytes / drug effects,  physiology
Sex Factors
Sister Chromatid Exchange / drug effects*
Sulfasalazine / therapeutic use,  toxicity*
Reg. No./Substance:

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