Document Detail


Increased sister-chromatid exchange frequency in patients receiving sulphasalazine therapy for ulcerative colitis.
MedLine Citation:
PMID:  6135986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sister-chromatid exchange and micronucleus frequencies are reported for lymphocytes cultured in vitro from 15 patients receiving sulphasalazine therapy for ulcerative colitis and 15 controls matched for age and sex. While the patients did not differ from matched controls for micronucleus frequency there was a substantial rise in their sister-chromatid exchange frequency. This evidence of DNA damage is discussed in relation to the known cancer risk that ulcerative colitis carries and the possibility of an increased mutation rate in the germ cells of those receiving sulphasalazine therapy.
Authors:
J M Mackay; D P Fox; P W Brunt; A W Johnston
Related Documents :
22094406 - Differential diagnosis of pulmonary embolism in outpatients with non-specific cardiopul...
22059486 - Effect of landiolol hydrochloride, an ultra-short-acting beta 1-selective blocker, on s...
16557376 - The role of scintigraphic defecography in the assessment of bowel function after restor...
17385106 - Narrow-band imaging compared with conventional colonoscopy for the detection of dysplas...
19247206 - Alterations of taste perception in crohn's disease and their dependency on disease acti...
3996836 - Reduction of cecal volvulus by multiple barium enemas.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  118     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-09-20     Completed Date:  1983-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-12     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking
Cell Nucleus / drug effects
Cells, Cultured
Colitis, Ulcerative
Crossing Over, Genetic / drug effects*
Female
Humans
Karyotyping
Lymphocytes / drug effects,  physiology
Male
Metaphase
Sex Factors
Sister Chromatid Exchange / drug effects*
Smoking
Sulfasalazine / therapeutic use,  toxicity*
Chemical
Reg. No./Substance:
599-79-1/Sulfasalazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Biochemical studies on Lowe's syndrome.
Next Document:  Nucleotide hydrolysis by solubilized membrane-bound enzymes of the brush border plasma membrane of H...