Document Detail


Increased sister chromatid exchange frequency at Xq27 site in affected fragile X males.
MedLine Citation:
PMID:  3591833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sister chromatid exchange (SCE) was evaluated in peripheral blood lymphocytes cultured from normal subjects, fragile X carrier females, and fragile X affected males and in general did not differ among all subjects whether cells were grown in thymidine-deficient or complete medium. However, at the Xq27 site, SCE was significantly increased for fragile X affected males, particularly in cells grown in thymidine-deficient medium.
Authors:
S L Wenger; J C Hennessey; M W Steele
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of medical genetics     Volume:  26     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  909-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Culture Media
Fragile X Syndrome / genetics*
Heterozygote
Humans
Male
Sex Chromosome Aberrations / genetics*
Sister Chromatid Exchange*
Grant Support
ID/Acronym/Agency:
SO7 RR0550723/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Culture Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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