Document Detail


Increased serum resistin levels in patients with coronary slow-flow phenomenon.
MedLine Citation:
PMID:  23400345     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Slow coronary flow (SCF) is an angiographic finding characterized by delayed opacification of the epicardial coronary arteries without obstructive coronary disease. Resistin, an adipocytokine, plays a major role besides low-grade inflammation in atherosclerotic vascular processes and may be of importance in other coronary pathologies such as SCF. METHODS: The present study was cross-sectional and observational, consisting of 70 individuals who underwent coronary angiography and had angiographically normal coronary arteries of varying coronary flow rates. The study included 50 patients with isolated SCF and 20 control participants with normal coronary flow (NCF). RESULTS: There were no statistically significant differences between the SCF and NCF groups with respect to age, gender, presence of hypertension or diabetes mellitus, and smoking habit, except for increased creatinine levels (p = 0.014). The serum resistin level was significantly higher in the SCF group than in the NCF group (8.4 ± 7.2 vs. 5.4 ± 2.6 ng/ml, p = 0.014). Ln-transformed resistin levels correlated positively with left anterior descending (LAD) coronary artery TIMI frame count (TFC) (r = 0.408, p < 0.001) as well as with glucose (r = 0.340, p = 0.004), creatinine (r = 0.248, p = 0.044), and C-reactive protein (CRP; r = 0.283, p = 0.023) levels, and negatively with LAD coronary flow velocity (r = - 0.314, p = 0.009). When multivariate analyses were performed, in linear regression analysis, ln-resistin was associated with a longer TFC [beta (standardized regression coefficient): 0.404, p = 0.001] and lower coronary flow velocity (beta: - 0.280, p = 0.035); in logistic regression analysis, ln-resistin was an independent predictor of the presence of SCF (OR: 6.692, 65 %CI: 1.117-40.1, p = 0.037). CONCLUSION: We demonstrated, for the first time, a significant increase in serum resistin levels in patients with SCF compared to subjects with NCF. We believe that further studies are needed to clarify the role of resistin in patients with SCF.
Authors:
A Canga; M Cetin; S A Kocaman; M E Durakoğlugil; A Kırbaş; T Erdoğan; A Temiz; A Yılmaz; Y Ciçek
Related Documents :
1401615 - Target lesion calcification in coronary artery disease: an intravascular ultrasound study.
24222825 - Obstructive sleep apnoea increases the incidence of morning peak of onset in acute myoc...
24782115 - Increased benefit of interleukin 1 inhibition on vascular function, myocardial deformat...
7634445 - Job strain and the prevalence and outcome of coronary artery disease.
2031415 - Diastolic time at ischemic threshold in patients with syndrome x.
10793175 - Triple therapy for acute myocardial infarction: combining fibrinolysis, platelet iib/ii...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-13
Journal Detail:
Title:  Herz     Volume:  -     ISSN:  1615-6692     ISO Abbreviation:  Herz     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Cardiology, Rize Education and Research Hospital, 53020, Rize, Turkey.
Vernacular Title:
Erhöhte Serumresistinspiegel bei Patienten mit dem Phänomen des langsamen Koronarflusses.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  QT interval prolongation during ECG evolution in takotsubo cardiomyopathy poses a threat of torsade ...
Next Document:  Aortic valve sclerosis is a high predictive marker of systemic endothelial dysfunction in hypertensi...