Document Detail

Increased serum oxidative stress in patients with severe mitral regurgitation: a new finding and potential mechanism for atrial enlargement.
MedLine Citation:
PMID:  19414007     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to examine the serum oxidative stress in patients with severe mitral regurgitation. DESIGN AND METHODS: This study analyzed serum oxidative stress index in patients with severe mitral regurgitation [persistent atrial fibrillation (AF) or sinus rhythm], paroxysmal lone AF patients and healthy subjects. RESULTS: The serum oxidative stress index was significantly higher in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). Left atrial size was significantly larger in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). The oxidative stress index significantly and positively correlated with left atrial size in the overall study population (r=0.439, p=0.0008). CONCLUSIONS: This study provides new evidence of increased oxidative stress in human severe mitral regurgitation, probably contributing to atrial enlargement.
Mien-Cheng Chen; Jen-Ping Chang; Wen-Hao Liu; Cheng-Hsu Yang; Chien-Jen Chen; Chih-Yuan Fang; Yuan-Kai Hsieh; Ya-Hui Wang; Hsueh-Wen Chang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-03
Journal Detail:
Title:  Clinical biochemistry     Volume:  42     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  943-8     Citation Subset:  IM    
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China.
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MeSH Terms
Antioxidants / metabolism
Heart Atria / metabolism*,  pathology*
Middle Aged
Mitral Valve Insufficiency / blood*,  metabolism*
Models, Cardiovascular
Oxidants / metabolism
Oxidative Stress*
Reg. No./Substance:
0/Antioxidants; 0/Oxidants

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