Document Detail


Increased serum oxidative stress in patients with severe mitral regurgitation: a new finding and potential mechanism for atrial enlargement.
MedLine Citation:
PMID:  19414007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of this study was to examine the serum oxidative stress in patients with severe mitral regurgitation. DESIGN AND METHODS: This study analyzed serum oxidative stress index in patients with severe mitral regurgitation [persistent atrial fibrillation (AF) or sinus rhythm], paroxysmal lone AF patients and healthy subjects. RESULTS: The serum oxidative stress index was significantly higher in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). Left atrial size was significantly larger in the mitral regurgitation AF group and sinus group than in the lone AF group and healthy subjects (p<0.0001). The oxidative stress index significantly and positively correlated with left atrial size in the overall study population (r=0.439, p=0.0008). CONCLUSIONS: This study provides new evidence of increased oxidative stress in human severe mitral regurgitation, probably contributing to atrial enlargement.
Authors:
Mien-Cheng Chen; Jen-Ping Chang; Wen-Hao Liu; Cheng-Hsu Yang; Chien-Jen Chen; Chih-Yuan Fang; Yuan-Kai Hsieh; Ya-Hui Wang; Hsueh-Wen Chang
Related Documents :
18190987 - Radiofrequency ablation of atrial fibrillation: the first 100 cases in lyon.
19801037 - Isolated left ventricular noncompaction syndrome.
20106797 - Different structural remodelling in atrial fibrillation with different types of mitral ...
3237967 - Perception of changes in eating disorder patients during group treatment.
15149307 - Therapy-resistant epilepsy in children: with the view of the long-term outcome.
6940237 - Granulocyte transfusions in acute leukaemia. regeneration of granulopoiesis as determin...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-03
Journal Detail:
Title:  Clinical biochemistry     Volume:  42     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  943-8     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung Hsien 83301, Taiwan, Republic of China. chenmien@ms76.hinet.net
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antioxidants / metabolism
Female
Heart Atria / metabolism*,  pathology*
Humans
Hypertrophy
Male
Middle Aged
Mitral Valve Insufficiency / blood*,  metabolism*
Models, Cardiovascular
Oxidants / metabolism
Oxidative Stress*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Oxidants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cortisol assays and diagnostic laboratory procedures in human biological fluids.
Next Document:  Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo.