| Increased serum levels of soluble vascular cell adhesion molecule-1 and E-selectin in patients with systemic sclerosis. | |
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MedLine Citation:
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PMID: 9851267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) in patients with systemic sclerosis (SSc). METHOD: Serum samples from 80 patients with SSc and 20 healthy control subjects were examined by a sensitive enzyme-linked immunosorbent assay. RESULTS: The serum levels of sVCAM-1 and sE-selectin were significantly higher in the patients with SSc than in the healthy controls. The serum levels of sVCAM-1 were correlated with the presence of pulmonary fibrosis, joint involvement and elevated erythrocyte sedimentation rate levels. The serum levels of sE-selectin were correlated with the presence of pulmonary fibrosis. CONCLUSION: These results suggest that endothelial activation is involved in the development of this disease. |
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Authors:
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H Ihn; S Sato; M Fujimoto; K Takehara; K Tamaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of rheumatology Volume: 37 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1998-12-30 Completed Date: 1998-12-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1188-92 Citation Subset: AIM; IM |
Affiliation:
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Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Sedimentation E-Selectin / blood* Enzyme-Linked Immunosorbent Assay Female Humans Joint Diseases / blood Male Matched-Pair Analysis Pulmonary Fibrosis / blood Scleroderma, Systemic / blood* Vascular Cell Adhesion Molecule-1 / blood* |
| Chemical | |
Reg. No./Substance:
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0/E-Selectin; 0/Vascular Cell Adhesion Molecule-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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