| Increased serum levels of neopterin and soluble interleukin-2 receptor in intrahepatic cholestasis of pregnancy. | |
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MedLine Citation:
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PMID: 15488124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The etiology of intrahepatic cholestasis of pregnancy (ICP), a pregnancy-specific complication, remains not completely understood. Some alterations of immunity in ICP were reported, but the profile of immune alteration was far from clarified. The aim of this investigation was to characterize the changes of serum levels of neopterin, a marker for the activation of macrophage, and soluble interleukin-2 receptor (sIL-2R), a marker for the activation of lymphocyte, in ICP. METHODS: Serum levels of neopterin and sIL-2R were assayed with enzyme linked immunosorbent assay (ELISA) in 30 patients with ICP and 30 normal pregnant women. Student's t-test was used for statistic analysis, and p < 0.05 was considered significant. RESULTS: Compared with control, serum levels of neopterin (p < 0.005) and sIL-2R (p < 0.05) were increased significantly in women with ICP. CONCLUSIONS: Activation of monocyte-macrophage and lymphocyte was demonstrated in ICP, and the participation of the activation of macrophage and lymphocyte in pathogenesis of the disease could be assumed. |
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Authors:
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Zhengping Wang; Minyue Dong; Hongnu Chu; Jing He |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 83 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-18 Completed Date: 2004-11-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 1067-70 Citation Subset: IM |
Affiliation:
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Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China. wangzp@zju.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Cholestasis, Intrahepatic / blood, immunology* Enzyme-Linked Immunosorbent Assay Female Humans Lymphocyte Activation Macrophage Activation Neopterin / blood* Pregnancy Pregnancy Complications / blood, immunology* Receptors, Interleukin-2 / blood* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Interleukin-2; 670-65-5/Neopterin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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