Document Detail

Increased serum levels of neopterin and soluble interleukin-2 receptor in intrahepatic cholestasis of pregnancy.
MedLine Citation:
PMID:  15488124     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The etiology of intrahepatic cholestasis of pregnancy (ICP), a pregnancy-specific complication, remains not completely understood. Some alterations of immunity in ICP were reported, but the profile of immune alteration was far from clarified. The aim of this investigation was to characterize the changes of serum levels of neopterin, a marker for the activation of macrophage, and soluble interleukin-2 receptor (sIL-2R), a marker for the activation of lymphocyte, in ICP. METHODS: Serum levels of neopterin and sIL-2R were assayed with enzyme linked immunosorbent assay (ELISA) in 30 patients with ICP and 30 normal pregnant women. Student's t-test was used for statistic analysis, and p < 0.05 was considered significant. RESULTS: Compared with control, serum levels of neopterin (p < 0.005) and sIL-2R (p < 0.05) were increased significantly in women with ICP. CONCLUSIONS: Activation of monocyte-macrophage and lymphocyte was demonstrated in ICP, and the participation of the activation of macrophage and lymphocyte in pathogenesis of the disease could be assumed.
Zhengping Wang; Minyue Dong; Hongnu Chu; Jing He
Related Documents :
6370474 - Malarial immunity in pregnant mice, in relation to total and unbound plasma corticoster...
9116874 - Fetal peripheral blood mononuclear cell proliferative responses to mitogenic and allerg...
11513544 - Preeclampsia, a pregnancy-specific disease, is associated with fetal monocyte activation.
8503994 - Is an additional vaccination necessary for a successful second pregnancy in unexplained...
17669404 - Combined treatment with temporary intraoperative balloon occlusion of common iliac arte...
24044744 - Embryonic diapause in humans: time to consider?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  83     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-18     Completed Date:  2004-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1067-70     Citation Subset:  IM    
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Case-Control Studies
Cholestasis, Intrahepatic / blood,  immunology*
Enzyme-Linked Immunosorbent Assay
Lymphocyte Activation
Macrophage Activation
Neopterin / blood*
Pregnancy Complications / blood,  immunology*
Receptors, Interleukin-2 / blood*
Reg. No./Substance:
0/Receptors, Interleukin-2; 670-65-5/Neopterin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Fetal home monitoring for the prenatal management of gastroschisis.
Next Document:  Neonatal outcome in a Danish national cohort of 8602 children born after in vitro fertilization or i...